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http://dx.doi.org/10.1126/science.adu1943 | DOI Listing |
Neurosurg Rev
September 2025
Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Purpose: To share our clinical experience with conservative management of isolated spinal arterial aneurysms (ISAs) and to identify clinical scenarios where conservative management may be appropriate, in the context of a literature review.
Methods: We performed a retrospective review of spinal angiograms from two German neuroradiology centers and conducted a systematic literature review of reported ISA cases. We analyzed demographics, clinical presentation, imaging findings, treatments, and outcomes.
J Med Chem
September 2025
Applied Pharmaceutical Science, Inc., Building 10-1, No.2, Jingyuan North Street, BDA, Beijing 100176, China.
This study reports the discovery and preclinical activity of APS03118, a novel selective RET inhibitor featuring a novel tricyclic pyrazolo[3',4':3,4]pyrazolo[1,5-]pyridine hinge-binding scaffold designed to overcome acquired resistance to first-generation selective RET inhibitors (SRIs). By enhancing hydrogen bonding with conserved hinge residues (Glu805, Ala807), APS03118 potently inhibits wild-type RET and diverse resistance mutations, including solvent-front (G810R/S/C), gatekeeper (V804M/L/E), roof (L730I/M), and hinge (Y806C/N/H) variants. In preclinical models, APS03118 induced complete tumor regression in KIF5B-RET and CCDC6-RET V804 M patient-derived xenografts (PDXs) and significantly prolonged survival in an intracranial CCDC6-RET metastasis model.
View Article and Find Full Text PDFIntegr Med Res
March 2026
Institute of Safety and Effectiveness Evaluation for Korean Medicine, Kyung Hee University, Seoul, South Korea.
Background: The number of injured workers using Traditional Korean Medicine (KM) soared from 752 in 2013 to 10,273 in 2023, yet this trend remains underexplored. This cross-sectional study examined the frequency and factors linked to KM and Western Medicine (WM) use among injured workers.
Methods: Data from 6,985 participants in the 2018 and 2023 waves of the Panel Study of Workers' Compensation Insurance (PSWCI) were analyzed.
J Surg Case Rep
September 2025
Department of Urology, The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, No. 6 of Qinren Road, Foshan 528000, Guangdong, People's Republic of China.
A 55-year-old female presented with left flank pain and ureteral obstruction. Imaging revealed a retroperitoneal mass suspicious for malignancy. Histopathology confirmed an inflammatory myofibroblastic tumor (IMT; anaplastic lymphoma kinase [ALK]-negative, mouse double minute 2 homolog-positive).
View Article and Find Full Text PDFAlcohol Clin Exp Res (Hoboken)
September 2025
Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Background: Fetal alcohol spectrum disorder (FASD) is a lifelong neurodevelopmental condition resulting from prenatal alcohol exposure (PAE) during gestation. Conservative estimates of FASD prevalence in United States children are 1%-5%. Early identification could facilitate early intervention, yet fewer than 1% of children with FASD receive a diagnosis.
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