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http://dx.doi.org/10.1097/CCM.0000000000006627 | DOI Listing |
Transfusion
July 2025
Vibrant Gene Consulting LLC, Cambridge, Massachusetts, USA.
Semin Thromb Hemost
May 2025
Laboratory of Hematology and Blood Bank Unit, "Attiko" Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece.
The transfusion of platelets and fresh frozen plasma (FFP) to critically ill neonates in neonatal intensive care units (NICUs) is a common intervention, yet it is still widely performed without adhering to international guidelines. The guidance itself on the therapeutic management of neonatal coagulation disorders is generally limited due to the absence of strong indications for treatment and is mainly aimed at the prevention of major hemorrhagic events such as intraventricular hemorrhage (IVH) in premature neonates. Historically, the underrepresentation of neonates in clinical studies related to transfusion medicine had led to significant gaps in our knowledge regarding the best transfusion practices in this vulnerable group and to a wide variability in policies among different neonatal units, often based on local experience or guidance designed for older children or adults, and possibly increasing the risk of inappropriate or ineffective interventions.
View Article and Find Full Text PDFTrauma Surg Acute Care Open
April 2025
Baylor College of Medicine, Michael E DeBakey Department of Surgery, Houston, Texas, USA.
The use of vasopressors during the acute resuscitation of severely injured patients with trauma has long been controversial. Building on the concept of permissive hypotension, damage control resuscitation focuses on hemostatic transfusion of blood products to maintain perfusion pressures. However, targeting lower perfusion pressures while awaiting definitive hemorrhage control is contraindicated in some patient subpopulations and may be detrimental.
View Article and Find Full Text PDFBiochem Mol Biol Educ
July 2025
Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
The COVID-19 pandemic began as a health crisis and quickly turned into an economic, social, and political crisis. It revealed the vulnerability of education systems to external changes and risks and challenged institutions and educators to transform and adapt at short notice. Following the COVID-19 outbreak, one of the natural consequences was the unprecedented rise in online education.
View Article and Find Full Text PDFJ Clin Med
March 2025
Department of Surgery, Division of Trauma, Surgical Critical Care, Burns, and Acute Care Surgery, University of Arizona, Tucson, AZ 85721, USA.
Hemorrhagic shock from traumatic injury results in a massive systemic response with activation of the hypothalamic-pituitary-adrenal (HPA) axis, pro-thrombotic and clot-lysis pathways as well as development of an endotheliopathy. With ongoing hemorrhage, these responses become dysregulated and are associated with worsening coagulopathy, microvascular dysfunction, and increased transfusion requirements. Our transfusion practices as well as our understanding of the molecular response to hemorrhage have undergone significant advancement during war.
View Article and Find Full Text PDF