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http://dx.doi.org/10.1038/s41375-025-02540-7 | DOI Listing |
J Eval Clin Pract
September 2025
Department of Orthopedics and Traumatology, Medical Faculty, University of Health Sciences, Antalya, Turkey.
Aims And Objective: The field of medical statistics has experienced significant advancements driven by integrating innovative statistical methodologies. This study aims to conduct a comprehensive analysis to explore current trends, influential research areas, and future directions in medical statistics.
Methods: This paper maps the evolution of statistical methods used in medical research based on 4,919 relevant publications retrieved from the Web of Science.
Genet Med
September 2025
Division of Medical Genetics, University of Washington School of Medicine.
Purpose: The fourth phase of the Electronic Medical Records and Genome Network (eMERGE4) is testing the return of 10 polygenic risk scores (PRS) across multiple clinics. Understanding the perspectives of health-system leaders and frontline clinicians can inform plans for implementation of PRS.
Methods: Fifteen health-system leaders and 20 primary care providers (PCPs) took part in semi-structured interviews.
Sex Reprod Health Matters
September 2025
Senior Research Scientist, Guttmacher Institute, New York, United States.
Since the release of the Supreme Court decision in June 2022, researchers have been working to better understand the impact that the growing number of abortion restrictions are having on the provision of and access to abortion services in the United States (US). Less is known about the impact of abortion restrictions on the provision of sexual and reproductive health (SRH) services more broadly, including at clinics that do not directly offer abortion. Between November 2023 and February 2024, we conducted interviews with SRH managers, clinic managers, and other administrators at publicly funded SRH clinics around the US to generate evidence on the effects of state-level abortion restrictions on the provision of abortion and related services, such as pregnancy options counselling and abortion referrals, at facilities providing contraceptive services.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Leibniz-Institut für Katalyse e.V. (LIKAT), Albert-Einstein-Str. 29a, Rostock 18059, Germany.
Metal-organic frameworks (MOFs) are transformative platforms for heterogeneous catalysis, but distinguishing atomically dispersed metal sites from subnanometric clusters remains a major challenge. This often demands the integration of multiple characterization techniques, many of which either lack the resolving power to distinguish active sites from their surrounding environments (e.g.
View Article and Find Full Text PDFNanoscale
September 2025
School of Biochemical Engineering, Indian Institute of Technology (BHU) Varanasi, Uttar Pradesh 221005, India.
Early-stage cancer diagnosis is considered a grand challenge, and even though advanced analytical assays have been established through molecular biology techniques, there are still clinical limitations. For example, low concentration of target biomarkers at early stages of cancer, background values from the healthy cells, individual variation, and factors like DNA mutations, remain the limiting factor in early cancer detection. Volatile organic compound (VOC) biomarkers in exhaled breath are produced during cancer cell metabolism, and therefore may present a promising way to diagnose cancer at the early stage since they can be detected both rapidly and non-invasively.
View Article and Find Full Text PDF