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At present, the C-arm structure accelerators commonly used in radiotherapy equipment are complex in operation and have potential safety hazards when realizing non-coplanar treatment. By combining with medical robotic arm technology, a spherical radiotherapy accelerator motion system is designed. The beam module is clamped by the medical robotic arm structure to achieve three-dimensional multi-angle irradiation treatment within the non-coplanar angle range. Firstly, the rotating mechanism, beam module, and MLC module of the spherical radiotherapy equipment are designed. Then, the double-plane counterweight method is used to calculate the dynamic balance of the equipment, ensuring that the beam center point does not rotate during the treatment process. Finally, the strength check and reliability analysis of the transmission component gear are conducted. The results show that the designed spherical radiotherapy accelerator motion system can meet the requirements of stable, accurate, and fast precision radiotherapy, which is conducive to improving the treatment efficiency.
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http://dx.doi.org/10.12455/j.issn.1671-7104.240288 | DOI Listing |
Med Phys
September 2025
Department of Accelerator and Medical Physics, National Institutes for Quantum Science and Technology (QST), Chiba, Japan.
Background: Multi-ion radiotherapy using carbon, oxygen, and neon ions aims to improve local control by increasing dose-averaged linear energy transfer (LET) in the target. However, there has been limited understanding of how to utilize variables for multi-ion treatment planning such as the selection and arrangement of ion species.
Purpose: An in silico study was conducted to explore the feasibility of increasing a minimum LET, and the optimal selection and arrangement of ion species in multi-ion therapy for increasing LET in tumors of varying sizes mimicking bone and soft tissue sarcomas (BSTS).
Nanomedicine (Lond)
September 2025
Faculty of Science, Biochemistry Department, Ege University, Izmir, Türkiye.
Aims: This study aims to develop biocompatible magnetic nanoparticles (MNPs) functionalized with tryptophan (Trp) and isatin (Isa), two biologically active molecules with known blood-brain barrier permeability and anticancer activity. The primary objective was to evaluate the potential of these functionalized MNPs for glioblastoma therapy.
Methods: Trp and Isa were conjugated onto MNPs, and the resulting nanomaterials were characterized using SEM-EDS, FTIR, XPS, and DLS.
Med Phys
August 2025
Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Background: The use of MR-guided radiation therapy (MRgRT) is increasing with the introduction of commercially-available parallel MR-linac systems. Treatment fields used by these machines can be very small and highly modulated. Literature on the small field dosimetry of parallel MR-linacs and the impact of the magnetic field on dose perturbations is scarce.
View Article and Find Full Text PDFPhys Eng Sci Med
July 2025
School of Chemistry and Physics, Queensland University of Technology (QUT), Brisbane, Australia.
Targeted alpha therapy (TαT) employs alpha particle-emitting radioisotopes conjugated to tumour-specific carriers to precisely irradiate tumour cells. Monte-carlo techniques have been used to accurately simulate absorbed dose and DNA damage for the four promising TαT radionuclides, Actinium-225 (Ac), Radium-223, (Ra), Lead-212 (Pb) and Astatine-211, (At). TOPAS and TOPAS-nBio, based on the Geant4 and Geant4-DNA monte-carlo codes respectively, were used to model the radioactive decay and alpha particle transport within a simplified spherical cell model.
View Article and Find Full Text PDFMed Phys
July 2025
Medical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Background: Radiobiological data suggests variations in relative biological effectiveness (RBE) between clinically used photon-based sources. A microdosimetric formalism using Monte Carlo (MC) methods can mechanistically describe the photon RBE. Experimentally derived RBE based on DNA double-strand breaks ( ) has been shown to scale with the microdosimetry quantity dose-mean lineal energy ( ).
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