Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1136/archdischild-2024-328202DOI Listing

Publication Analysis

Top Keywords

clinical utility
4
utility salivary
4
salivary androgen
4
androgen profiles
4
profiles diagnostic
4
diagnostic tool
4
tool premature
4
premature adrenarche
4
adrenarche pilot
4
pilot study
4

Similar Publications

Background: Chest radiography is often performed preoperatively as a common diagnostic tool. However, chest radiography carries the risk of radiation exposure. Given the uncertainty surrounding the utility of preoperative chest radiographs, physicians require systematically developed recommendations.

View Article and Find Full Text PDF

Self-Propelled Magnetic Micromotor-Functionalized DNA Tile System for Autonomous Capture of Circulating Tumor Cells in Clinical Diagnostics.

Adv Sci (Weinh)

September 2025

Key Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital, NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine & The Second Affiliated Hospital, Hainan Medical University, Haikou, 571199, China.

Circulating tumor cells (CTCs) carry intact tumor molecular information, making them invaluable for personalized cancer monitoring. However, conventional capture methods, relying on passive diffusion, suffer from low efficiency due to insufficient collision frequency, severely limiting clinical utility. Herein, a magnetic micromotor-functionalized DNA-array hunter (MMDA hunter) is developed by integrating enzyme-propelled micromotors, magnetic nanoparticles, and nucleic acid aptamers into distinct functional partitions of a DNA tile self-assembly structure.

View Article and Find Full Text PDF

Purpose: The fourth phase of the Electronic Medical Records and Genome Network (eMERGE4) is testing the return of 10 polygenic risk scores (PRS) across multiple clinics. Understanding the perspectives of health-system leaders and frontline clinicians can inform plans for implementation of PRS.

Methods: Fifteen health-system leaders and 20 primary care providers (PCPs) took part in semi-structured interviews.

View Article and Find Full Text PDF

Objectives: The Charlson comorbidity index reflects overall comorbidity burden and has been applied in cardiovascular medicine. However, its role in predicting in-hospital mortality in patients with acute myocardial infarction (AMI) complicated by ventricular arrhythmias (VA) remains unclear. This study aims to evaluate the predictive value of the Charlson comorbidity index in this setting and to construct a nomogram model for early risk identification and individualized management to improve outcomes.

View Article and Find Full Text PDF

In the 21st century, cancer remains shrouded in complex ways, imbued with sociocultural meanings that extend far beyond its clinical and biological aspects. The fear and anxiety surrounding cancer often prompt family and friends to respond with either excessive protection or emotional detachment, leaving patients feeling isolated and unsupported. This article challenges entrenched stereotypes, particularly cultural tendencies in India to conceal cancer diagnoses, associate the disease with karmic retribution, and view it through fatalistic and death-centered perspectives.

View Article and Find Full Text PDF