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Objectives: The objective of this study was to develop the weightage identified network of keywords (WINK) technique for selecting and utilizing keywords to perform systematic reviews more efficiently. This technique aims to improve the thoroughness and precision of evidence synthesis by employing a more rigorous approach to keyword selection.
Methods: The WINK methodology involves generating network visualization charts to analyze the interconnections among keywords within a specific domain. This process integrates both computational analysis and subject expert insights to enhance the accuracy and relevance of the findings. In the example considered, the networking strength between the contexts of environmental pollutants with endocrine function as Q1 and systemic health with oral health-related terms as Q2 was examined, and keywords with limited networking strength were excluded. Utilizing the Medical Subject Headings (MeSH) terms identified from the WINK technique, a search string was built and compared to an initial search with fewer keywords.
Results: The application of the WINK technique in building the search string yielded 69.81% and 26.23% more articles for Q1 and Q2, respectively, compared to conventional approaches. This significant increase demonstrates the technique's effectiveness in identifying relevant studies and ensuring comprehensive evidence synthesis.
Conclusions: By prioritizing keywords with higher weightage and utilizing network visualization charts, the WINK technique ensures comprehensive evidence synthesis and enhances accuracy in systematic reviews. Its effectiveness in identifying relevant studies marks a significant advancement in systematic review methodology, offering a more robust and efficient approach to keyword selection.
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http://dx.doi.org/10.4258/hir.2025.31.1.48 | DOI Listing |
Transl Vis Sci Technol
September 2025
Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Purpose: The purinergic receptor P2X4 is critical to transduction of ocular pain. The aim of this study was to investigate the therapeutic potential of the P2X4 receptor antagonist BAY-776 in alleviating chronic ocular pain.
Methods: Chronic ocular pain was induced in male rats (8-9 weeks old; n = 12 per group) via double lacrimal gland removal (DLGR).
BMJ Public Health
August 2025
Health and Society Group, Social Science Department, Wageningen University & Research, Wageningen, Gelderland, The Netherlands.
Introduction: Improving health, in particular of people in a disadvantaged socioeconomic position (SEP), requires multilevel health promotion programmes with community engagement. However, the impacts of such complex and challenging programmes are not yet clear. This study aims to show the impact of a participatory multilevel family health promotion programme in a low-income neighbourhood at intrapersonal, interpersonal, organisational, community and policy level.
View Article and Find Full Text PDFArch Soc Esp Oftalmol (Engl Ed)
September 2025
Grupo de investigación GIESVI, Facultad de Optometría, Universidad Santo Tomás, Bucaramanga, Colombia.
Objective: To determine the state of ocular surface and tear film in college students who are users of inhalants, mainly vapers.
Methods: We conducted a descriptive, observational, and cross-sectional study with 62 participants whose sociodemographic characteristics, ocular surface status, tear film and variables related to vaping were evaluated. Individuals with a higher (5-7 times per week of consumption) and lower frequency of vaping (1-4 times per week of consumption) were evaluated.
Clin Neurophysiol
September 2025
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Objective: To compare brain activity before voluntary movement and before the same movement when it was released from suppression. This study examined the Bereitschaftspotential (BP) and beta band event-related desynchronization (bERD) during active blink suppression, contrasting these with voluntary blinking, where these EEG correlates of motor preparation are well-established.
Methods: Fifteen healthy adults performed voluntary blink and blink suppression-release tasks with EEG recording.
Clin Ophthalmol
August 2025
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, People's Republic of China.
Objective: To explore alterations in tears and ocular surface throughout Descemet's Membrane Endothelial Keratoplasty (DMEK), thereby offering valuable insights for clinical intervention.
Methods: This study was conducted on 84 patients (84 eyes) with CED and received DMEK who visited the Zhongshan Ophthalmic Center of Sun Yat-sen University from April 2022 to January 2024. All patients were evaluated preoperatively and 1, 3, 6, and 12 months postoperatively, with 31 patients (31 eyes) post-24 months above.