98%
921
2 minutes
20
This review delves into the emerging field of cerebellar Transcranial Magnetic Stimulation (TMS) in the rehabilitation of limb dysfunction following a stroke. It synthesizes findings from randomized controlled trials and case studies, examining the efficacy, safety, and underlying mechanisms of cerebellar TMS. The review outlines advancements in TMS technologies, such as low-frequency repetitive TMS, intermittent Theta Burst Stimulation, and Cerebello-Motor Paired Associative Stimulation, and their integration with physiotherapy. The role of the cerebellum in motor control, the theoretical underpinnings of cerebellar stimulation on motor cortex excitability, and the indirect effects on cognition and motor learning are explored. Additionally, the review discusses current challenges, including coil types, safety, and optimal timing and modes of stimulation, and suggests future research directions. This comprehensive analysis highlights cerebellar TMS as a promising, though complex, approach in stroke rehabilitation, offering insights for its clinical optimization.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830664 | PMC |
http://dx.doi.org/10.3389/fnins.2025.1405637 | DOI Listing |
J Neurophysiol
September 2025
School of Health and Human Sciences, Indiana University Indianapolis, Indianapolis, IN, USA.
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that can alter the excitability of targeted brain regions and influence motor learning. For the first experiment, we studied the effects of several individual stimulation montages (2mA) on motor learning in a complex rhythm-timing video game task (n=79, M1 anodal tDCS [M1 a-tDCS], Cerebellar anodal tDCS [CB a-tDCS], Cerebellar cathodal tDCS [CB c-tDCS], and SHAM). Performance was assessed using a performance index (PI) incorporating keystroke timing accuracy, tap distribution ratio, and key error rate.
View Article and Find Full Text PDFPLoS One
September 2025
Scientific Institute, IRCCS E. Medea, Bosisio Parini (LC), Italy.
Background: Children with cerebral palsy (CP) commonly face gross motor function impairments and manual dexterity deficits, significantly affecting their activity level and independence and, ultimately, quality of life. Rehabilitation often targets improving manual dexterity and activity levels, but standard therapies have limited efficacy. Hence, exploring novel methods to enhance upper limb functionality is crucial.
View Article and Find Full Text PDFBrain Stimul
August 2025
Department of Neurology, Comprehensive Stroke Center, University of California Los Angeles (UCLA), USA.
Sci Rep
August 2025
Physical Therapy Department, Rehabilitation Faculty, Tehran University of Medical Sciences, P. O. Box: 16535-188, Tehran, Iran.
Falls pose a significant health risk for older adults, with most incidents occurring during dual-task situations-when walking is combined with a secondary cognitive task. Reducing cognitive-motor interference and attentional demands during walking is therefore a key goal in effective fall-prevention and rehabilitation programs. High-definition transcranial direct current stimulation (HD-tDCS) is an emerging neuromodulation technique that may support this goal by enhancing neural efficiency.
View Article and Find Full Text PDFPain Ther
August 2025
Department of Neurology, University Hospital Würzburg, Josef-Schneider-Straße 11, Haus B1, 97080, Würzburg, Germany.
Introduction: Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) has been shown to reduce the symptoms of patients with fibromyalgia syndrome (FMS). We tested whether rTMS of the left DLPFC can reduce the main symptoms in FMS and whether TMS induces changes in brain functional and structural connectivity, cortical gray matter volume, and the metabolites/neurotransmitters GABA and combined glutamate/glutamine (Glx).
Methods: Twenty-seven women diagnosed with FMS according to the 2010 ACR criteria were included in a randomized controlled trial.