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| http://dx.doi.org/10.1016/j.brs.2025.08.020 | DOI Listing |
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Transcranial ultrasound localization microscopy of the rat brain with ray theory-based aberration correction.
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College of Biomedical Engineering, Fudan University, Shanghai 200438, China; State Key Laboratory of Integrated Chips and Systems, Fudan University, Shanghai 200438, China; Poda Medical Technology Co., Ltd., Shanghai 200433, China. Electronic address:
Transcranial ultrasound localization microscopy (t-ULM) is faced with challenges posed by the skull, including acoustic attenuation and phase aberrations. There is a significant request for an efficient aberration correction method achieving a great balance between computational complexity and accuracy. In this study, the ray theory is first applied to in-vivo transcranial imaging to calculate the traveltime table in the inhomogeneous medium model of the imaging region.
View Article and Find Full Text PDFTranscranial ultrasonic stimulation of cerebellar fastigial nucleus: First-in-Human feasibility study.
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Department of Neurology, Comprehensive Stroke Center, University of California Los Angeles (UCLA), USA.
The use of alendronate to enhance transcranial transmission of focused ultrasound for successful ablations in brain.
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Lomonosov Moscow State University, Leninskiye Gory 1/2, Moscow, 119992, Russia.
Objective: The aim of this study was to evaluate the efficacy of alendronate therapy in improving bone density distribution in skull bones and corresponding ultrasound permeability in patients who had previously experienced unsuccessful transcranial MR-guided focused ultrasound (MRgFUS) ablation. The ability of alendronate treatment to modify skull bone characteristics and enhance the success rate of repeat MRgFUS procedures was assessed.
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Functional connectivity between the cerebellum and the motor cortex is critical for motor function. Low-intensity transcranial ultrasound stimulation (TUS) has been proved to directly activate cerebellar neural activity. However, whether and how TUS of the cerebellum modulates neural activity in the motor cortex is unclear.
View Article and Find Full Text PDFFocused ultrasound combined with drug-loaded microbubbles suppresses ictal spikes in kainic acid-induced epileptic animals.
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Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan; Medical Device Innovation Center, National Cheng Kung University, Tainan, Taiwan; Center of Transformative Bioelectronic Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic add
Current epilepsy treatments include anti-seizure medications (ASMs), surgical interventions, and neuromodulation. However, achieving precise, non-invasive seizure control continues to pose a significant clinical challenge. Transcranial-focused ultrasound (FUS) combined with microbubbles (MBs) has been employed to enhance localized chemotherapy drug delivery for brain tumors, yet its potential for improving ASMs delivery and modulating epileptic excitability has yet to be investigated.
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