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http://dx.doi.org/10.1016/j.scib.2025.01.050 | DOI Listing |
Blood Adv
September 2025
University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Historically, Sickle Cell Disease (SCD) has been overshadowed by progress in other hematologic disorders, but recent advances are reshaping its clinical and research landscape. Despite SCD reducing life expectancy by more than 20 years even with optimal care, transformative initiatives are fostering hope for improved outcomes. The American Society of Hematology (ASH) established the ASH Research Collaborative Sickle Cell Disease Research Network as a comprehensive program to revolutionize SCD research in the United States.
View Article and Find Full Text PDFJ Neuropathol Exp Neurol
September 2025
Department of Neurological Surgery, University of California San Francisco (UCSF), San Francisco, CA, United States.
Advances in digital pathology and machine learning have the potential to revolutionize diagnostic neuropathology. Current brain tumor models are typically trained and validated using morphologic features from a single hematoxylin and eosin (H&E)-stained slide per patient. Yet, brain tumors such as diffuse glioma are known for their epigenetic, genetic, and transcriptional heterogeneity within an individual patient.
View Article and Find Full Text PDFACS Appl Bio Mater
September 2025
Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Saharanpur campus, Saharanpur, 247001, Uttar Pradesh India.
Smart packaging is revolutionizing the food industry by extending shelf life and enhancing quality, thus ensuring food safety and sustainability. This study presents innovative multilayer flexible packaging films to tackle the environmental challenges of single-use plastics and nonrecyclable metalized multilayer films. The fabricated films comprise three layers made up of poly(lactic acid) (PLA), poly(vinyl alcohol)/natural rubber latex, and PLA/Sepiolite clay from inner to outer, respectively, where the active middle layer provides oxygen-scavenging activity.
View Article and Find Full Text PDFJACS Au
August 2025
International College of Semiconductor Technology, National Yang Ming Chiao Tung University, 1001 Daxue Road, Hsinchu 300093, Taiwan.
The development of high-performance lithium-sulfur batteries (LSBs) has been focused on overcoming the limitations associated with traditional polysulfide catholyte synthesis. We report an innovative catholyte synthesis method using lithium-arene complexes, offering significant advancements in terms of solubility, stability, and scalability. By leveraging the interaction of metallic lithium with biphenyl (BP) and sulfur, we developed a Li+BP+S catholyte formulation that outperforms conventional LiS+S systems.
View Article and Find Full Text PDFJ Mater Chem B
August 2025
School of Mechanical Engineering, Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing, Jiangsu Province 211189, P. R. China.
In early cancer diagnosis, extracellular vesicles (EVs) are more advantageous than circulating tumor cells due to their smaller size, greater stability, and enhanced tissue penetration. These qualities lead to higher EV concentrations in body fluids, facilitating early detection. This study leverages surface-enhanced Raman scattering (SERS) for EV detection, employing a novel biosensor made with a molybdenum disulfide (MoS) composite film on silicon and demonstrating a lower limit of detection (LOD) and multi-marker synchronous quantitative testing performance compared to existing methodologies.
View Article and Find Full Text PDF