Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The practice of collecting various intraoperative tissue samples from diverse periarticular sites is essential for accurately identifying the responsible microorganism, making it the gold standard in the procedure for managing periprosthetic joint infection (PJI). We hypothesized that the location of positive intraoperative cultures differs significantly between patients who underwent septic revision following a one-stage exchange for hip PJI and those who did not.
Methods: We conducted a retrospective case-control study at our tertiary arthroplasty center, analyzing data from January 2009 to September 2017. Our search identified 56 patients who experienced septic failure following one-stage hip revision arthroplasty for PJI. These patients were matched 1:1 by age, sex, and surgery date with a control group who had successful one-stage revision total hip arthroplasty (THA) without septic failure. Positive intraoperative tissue samples were categorized into three locations: soft tissue, bone-prosthesis interface (superficial bone), and deep bone (intramedullary).
Results: The septic failure cohort demonstrated a statistically significant increase in both the Charlson Comorbidity Index and Body Mass Index compared to the control group (P < 0.001 and P = 0.01, respectively). Furthermore, a significantly greater number of positive superficial and deep bone culture samples were identified within the septic failure group (P < 0.001 and P < 0.001, respectively). In addition, regression analysis indicated that a positive deep bone culture is associated with nearly a three-fold increase in the odds of reinfection, with an odds ratio of 2.8 (95% confidence interval: 1.1 to 7.3, P = 0.031).
Conclusions: A positive deep bone culture sample is significantly correlated with septic failure following a one-stage exchange for PJI of the hip. Patients exhibiting positive deep bone cultures may derive benefit from extended postoperative antibiotic therapy for the treatment of infection, as well as rigorous monitoring and evaluation of inflammatory markers during the follow-up phases subsequent to one-stage exchange arthroplasty.
Level Of Evidence: Level III.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.arth.2025.02.034 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Vitamin C Does Not Affect Platelet Counts in Patients With Sepsis: A Post hoc Analysis of the Lessening Organ Dysfunction With Vitamin C Randomized Trial.
Crit Care Explor
September 2025
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Objective: Vitamin C has been linked to alterations in platelet count and aggregation behavior. Given recent findings suggesting an association between vitamin C and adverse outcomes in patients with septic shock, we aimed to investigate whether vitamin C influences mortality in septic patients through its impact on platelets.
Design: Post hoc analysis of the Lessening Organ Dysfunction With Vitamin C (LOVIT) randomized trial (clinicaltrials.
Oxygen targets in patients with septic shock: a retrospective cohort study on the association between hyperoxia and mortality.
Front Med (Lausanne)
August 2025
Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Background: In critically ill patients with septic shock, adequate oxygenation is crucial and hypoxia should be avoided. However, hyperoxia has been linked to the formation of reactive oxygen species, inflammation, and vasoconstriction, which could potentially harm critically ill intensive care patients. Therefore, this study aimed to examine the association between oxygen exposure and mortality and to define optimal oxygen target ranges for this specific group of patients.
View Article and Find Full Text PDFPro- and Anti-Inflammatory Responses and Clinical Outcomes in Critically Ill Patients With Endotheliopathy: A Cohort Study.
Acta Anaesthesiol Scand
October 2025
Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark.
Background: Multiple organ dysfunction syndrome (MODS) in critical illness involves dysregulated immune and inflammatory responses, endotheliopathy, and coagulation activation. We investigated how three types of endotheliopathy biomarkers relate to pro- and anti-inflammatory responses and clinical outcomes in intensive care unit (ICU) patients.
Methods: In this secondary, explorative analysis of a prospective single-centre cohort (n = 459), we assessed associations between endotheliopathy biomarkers (syndecan-1, soluble thrombomodulin (sTM), platelet endothelial cell adhesion molecule-1 (PECAM-1)) and inflammatory biomarkers (pro-inflammatory: IFN-ϒ, IL-1β, IL-2, IL-6, IL-8, IL-12p70, TNF-α; anti-inflammatory: IL-4, IL-10, IL-13) at ICU admission using linear regression.
Sepsis following hysteroscopic removal of retained products of conception: A case report and literature review.
Medicine (Baltimore)
September 2025
Department of Ultrasound, Hangzhou Women's Hospital, Hangzhou, Zhejiang Province, P. R. China.
Rationale: Sepsis following hysteroscopy is an rare complication, with current evidence suggesting that routine prophylactic antibiotic administration may not be warranted. However, this does not imply that we should disregard vigilance regarding the potential occurrence of severe infections post-hysteroscopy.
Patient Concerns: A 27-year-old female underwent hysteroscopic resection of retained products of conception after incomplete medical abortion.
Impact of Metabolically Healthy and Unhealthy Obesity on Outcomes of Sepsis Complicated by Septic Shock in Elderly Patients.
J Intensive Care Med
September 2025
Independent Researcher, Outcomes Research, Atlanta, GA, USA.
Purpose: Obesity is a risk factor for sepsis complications in older adults. We assessed the impact of metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO) on outcomes in septic shock.
Methods: We conducted a retrospective analysis using the National Inpatient Sample (2016-2020) to identify a cohort of 1,737,075 patients aged 65 years and older who were hospitalized with septic shock, as defined by ICD-10 diagnosis codes.