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Life cycle assessment (LCA), coupled with process modeling to develop the life cycle inventory, is a valuable tool to assess differences in environmental performance when evaluating alternatives based on sustainability (triple-bottom-line) principles. Coupled with a whole plant process model (SUMO21), an LCA assessed the environmental performance of options to upgrade biosolids management for the Great Lakes Water Authority water resource recovery facility. All five alternatives evaluated (composting plus four anaerobic digestion alternatives) were able to meet the core objectives of the biosolids management system upgrade: (1) address ageing incinerators, (2) minimize the mass of biosolids landfilled, and (3) reduce greenhouse gas emissions, compared to the existing (baseline) system. The mass of solids to be managed was reduced for the anaerobic digestion alternatives but not for the composting alternatives. Environmental impacts were reduced for the composting alternative for all six impact categories considered (global warming, eutrophication, carcinogenics, ecotoxicity, respiratory effects, and fossil fuel depletion) relative to the baseline, and further reduced for all four anaerobic digestion alternatives evaluated. The results allowed a phased implementation plan to be developed, which could be evaluated based on other factors, such as costs and operational factors.
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http://dx.doi.org/10.2166/wst.2025.008 | DOI Listing |
JAMA Netw Open
September 2025
School of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Importance: The cost-effectiveness of adding early in-bed cycling to usual physiotherapy among adults receiving mechanical ventilation in the intensive care unit (ICU) compared with usual physiotherapy alone is unknown.
Objective: To evaluate the cost-effectiveness of in-bed cycling plus usual physiotherapy compared with usual therapy alone in the Critical Care Cycling to Improve Lower Extremity Strength (CYCLE) randomized clinical trial.
Design, Setting, And Participants: This trial-based economic evaluation with a 90-day time horizon compared early cycling plus usual physiotherapy vs usual physiotherapy alone from a societal perspective.
mSphere
September 2025
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, USA.
Apicomplexan AP2 (ApiAP2) family proteins are a family of transcription factors that are known to regulate gene expression in apicomplexan pathogens, including . In this study, we focused on TgAP2X-7, a member of the APiAP2 family that is predicted to be essential for fitness. Endogenous tagging of TgAP2X-7 followed by immunofluorescence analysis revealed that it's a cell cycle-regulated nuclear protein with peak expression in the G1 phase.
View Article and Find Full Text PDFElife
September 2025
Graduate School of Life Science, Hokkaido University, Sapporo, Japan.
DNA replication requires recruitment of Cdc45 and GINS into the MCM double hexamer by initiation factors to form an active helicase, the Cdc45-MCM-GINS (CMG) complex, at the replication origins. The initiation factor Sld3 is a central regulator of Cdc45 and GINS recruitment, working with Sld7 together. However, the mechanism through which Sld3 regulates CMG complex formation remains unclear.
View Article and Find Full Text PDFmBio
September 2025
Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture and Rural Affairs, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Unlabelled: Fungal degradation of cellulose facilitates the sustainable harnessing of biosphere energy and carbon cycling. is one of the basidiomycetes with the largest number of hydrolytic enzymes in its genome. The mycelium of degrades cellulose through the production of substantial amounts of cellulase, enabling the absorption of carbon sources and nutrients essential for fruiting body development.
View Article and Find Full Text PDFDiabetes Metab Syndr Obes
September 2025
Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
Background: Antipsychotics are associated with side effects like weight gain, obesity, and menstrual disorders in Women, which can reduce treatment compliance and increase cardiovascular, metabolic risks, dementia, and other chronic diseases, as well as increase mortality, and reduce the quality of life in patients. Data on these effects in Vietnam are limited. This study evaluated changes in body weight, BMI, menstrual cycle, and metabolic syndrome components among female schizophrenic inpatients treated with antipsychotics.
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