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Pyoderma caused by methicillin-resistant Staphylococcus pseudintermedius poses significant challenges to canine health. Successful therapy requires an integrated approach to prudent antimicrobial use. This report describes the successful treatment of a dog with generalised superficial pyoderma using a topical formulation of S. pseudintermedius phage applied once daily for a period of 30 days.
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http://dx.doi.org/10.1111/vde.13328 | DOI Listing |
J Dermatolog Treat
December 2025
Department of Dermatology, Peking University Third Hospital, Beijing, China.
Aim: To evaluate the therapeutic efficacy and safety of the Janus kinase (JAK) inhibitor tofacitinib in the management of refractory perianal pyoderma gangrenosum (PG) under conditions of baseline immunosuppression and bone marrow suppression.
Methods: We present a 62-year-old male with a 4-month history of painful, progressive symmetrical perianal ulcerations diagnosed as PG, coexisting with condyloma acuminatum. The patient had a background of pure red cell aplasia and myasthenia gravis, and was undergoing chronic immunosuppressive therapy with prednisolone and tacrolimus.
J Surg Res
September 2025
Nationwide Children's Hospital, Abigail Wexner Research Institute, Columbus, Ohio; Department of Plastic and Reconstructive Surgery, Nationwide Children's Hospital, Columbus, Ohio; Pediatric Comprehensive Wound Program, Nationwide Children's Hospital, Columbus, Ohio. Electronic address: Jenny.Barker
Introduction: Chronic wounds affect approximately 10.5 million individuals annually in the United States. Although recent studies have highlighted a surge in chronic wound cases among younger populations, the collective burden of pediatric chronic wounds remains understudied.
View Article and Find Full Text PDFJ Am Anim Hosp Assoc
September 2025
From Animal Dermatology Clinic, Marietta, Georgia (A.B., J.G.).
Dogs with hyperadrenocorticism (HAC) present to a referral dermatology practice with clinical signs that vary from the traditional HAC signs. This retrospective case series evaluates the presenting complaints, history findings, and physical examination findings in dogs diagnosed with HAC presenting to a referral dermatology practice. Medical records of 30 dogs diagnosed with HAC and evaluated at a private dermatology referral practice were retrospectively reviewed.
View Article and Find Full Text PDFJ Small Anim Pract
August 2025
Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Objectives: The aim of this study was to evaluate the reported bacteria and antibiotic sensitivities of aerobic bacterial cultures taken from the same lesion and submitted to three different laboratories. The second objective was to evaluate the clinical significance of the results.
Materials And Methods: Three cultures were collected simultaneously from the same lesion (crusts, collarettes or pustules).
N Z Vet J
August 2025
Technical Services, Faculty of Science, Auckland University, Auckland, New Zealand.
Aims: First, to determine via whole genome sequencing the sequence of the gene that encodes δ-toxin and elements of the accessory gene regulator () locus that encode quorum sensing in four isolates from atopic dogs; second, to assess degranulation of mast cells by synthetic δ-toxin and by culture filtrate containing δ-toxin from the isolates in canine skin ; and third, to determine whether the genetic region () encoding the δ-toxin gene is upregulated in response to increasing bacterial density (quorum sensing) in the isolates.
Methods: Four isolates of were obtained from four dogs with pyoderma and canine atopic dermatitis (cAD). All four isolates were sequenced to compare their genomes and the sequences of the and elements.