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This paper investigates the effect of adding 0.1 % Y and 0.1 % Zr microalloying on the microstructure and corrosion resistance behavior of Al-5.5Mg-0.3Mn alloys sensitization treatment. The results show that the composite addition of Y and Zr could refine the grain structure and reduce the segregation of the Mg elements during casting. Some micro-scale AlMgYZr phases could also be found in the interior region of grains. After sensitization treatment, nano-sized Al(Y, Zr) particles induce a high proportion of low-angle grain boundaries (LAGBs) in the alloy, and the AlMgYZr phase suppresses the precipitation and coarsening of β phase (AlMg) at the grain boundaries (GBs). The refinement of the β phase reduces the micro-coupling corrosion effect at GBs and improves the intergranular corrosion (IGC) resistance of the alloy. The electrochemical self-corrosion voltage of the alloy is increased, and the self-corrosion current is decreased.
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http://dx.doi.org/10.1016/j.micron.2025.103789 | DOI Listing |
Mol Ther
September 2025
Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis, partly due to cancer stem cells (CSCs) that drive progression and treatment resistance. We explored the therapeutic potential of inducing cuproptosis, a copper-dependent regulated cell death, in CSC-enriched PDAC models. Using human and murine PDAC models, we evaluated elesclomol, a copper transport enhancer.
View Article and Find Full Text PDFJ Colloid Interface Sci
September 2025
College of Marine Life Science, Ocean University of China, Qingdao 266003, China. Electronic address:
Despite the tremendous potential of cancer immunotherapy, its clinical benefits remain limited. Cytotoxic T lymphocyte (CTL)-mediated immune responses rely on the secretion of perforin and granzyme B (GZMB) to induce apoptosis in tumor cells. The mannose-6-phosphate receptor (M6PR) on tumor cell membranes can recognize GZMB and promote its internalization in a perforin-independent manner.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
The mutagenic translesion synthesis (TLS) pathway, which is critically dependent on REV1's ability to recruit inserter TLS polymerases and the POLζ extender polymerase, enables cancer cells to bypass DNA lesions while introducing mutations that likely contribute to the development of chemotherapy resistance and secondary malignancies. Targeting this pathway represents a promising therapeutic strategy. Here, we demonstrate that the expression of the C-terminal domain (CTD) of human REV1, a ca.
View Article and Find Full Text PDFFront Immunol
September 2025
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
NSG-SGM3 humanized mouse models are well-suited for studying human immune physiology but are technically challenging and expensive. We previously characterized a simplified NSG-SGM3 mouse, engrafted with human donor CD34 hematopoietic stem cells without receiving prior bone marrow ablation or human secondary lymphoid tissue implantation, that still retains human mast cell- and basophil-dependent passive anaphylaxis responses. Its capacities for human antibody production and human B cell maturation, however, remain unknown.
View Article and Find Full Text PDFCureus
August 2025
Physiology, SGT University, Gurugram, IND.
Introduction Simulation-based training has been a vital part of medical education since Competency-Based Medical Education (CBME) was introduced, and new guidelines since 2023 have expanded to include simulation as a mandatory methodology of teaching. This method enables learners to build and develop both technical and non-technical abilities in a safe and controlled setting, enhancing their preparedness for real-life medical scenarios. Simulation-based training improves skill acquisition and retention and enhances learners' confidence, reduces anxiety, reinforces learning, corrects errors, and promotes reflective practice, in contrast with the traditional method of teaching.
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