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http://dx.doi.org/10.14309/ajg.0000000000003357 | DOI Listing |
RSC Adv
August 2025
Department of Chemistry, University of North Carolina Charlotte Charlotte NC 28223 USA
Photodynamic therapy (PDT) is a minimally invasive treatment modality that offers an alternative or supplementary approach to chemotherapy and surgery, characterized by low toxicity and reduced side effects. PDT has been applied to various cancers, often in combination with other therapies to enhance its efficacy. The therapy relies on three main components: a photosensitizer (PS), light of a specific wavelength, and molecular oxygen (O).
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Ultrasound Diagnostic Center, The First Hospital of Jilin University, Changchun, China.
Objective: This study aims to construct a multimodal radiomics model based on contrast-enhanced ultrasound (CEUS) radiomic features, combined with conventional ultrasonography (US) images and clinical data, to evaluate its diagnostic efficacy in differentiating benign and malignant thyroid nodules (TNs) classified as C-TIRADS 4, and to assess the clinical application value of the model.
Methods: This retrospective study enrolled 135 patients with C-TIRADS 4 thyroid nodules who underwent concurrent US and CEUS before FNA/surgery. From each case, one US image and three CEUS key frames (2s post-perfusion, peak enhancement, 2s post-peak) were selected.
Clin Neurophysiol
August 2025
Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.
Objective: Cortical speech mapping using navigated Transcranial Magnetic Stimulation (nTMS) has a variable positive predictive value (PPV) when compared with intraoperative direct electrical stimulation.
Methods: This is a single centre prospective study of all patients undergoing pre-operative nTMS and tractography (frontal aslant tract (FAT) and arcuate fasciculus (AF)) for awake surgery between October 2018 and November 2023. We reviewed operative notes for speech arrest, collected data on demographics, histopathology and pre-/post-operative language assessment.
Ann Med Surg (Lond)
September 2025
Department of Biomedical and Laboratory Science, Africa University, Mutare, Zimbabwe.
Venous thromboembolism (VTE) remains a significant cause of morbidity and mortality in breast cancer patients, particularly in those with advanced disease or undergoing systemic therapies. While breast cancer is not traditionally classified among the most thrombogenic malignancies, accumulating evidence suggests that tumor biology, treatment modalities, and systemic inflammation can collectively heighten thrombotic risk. This has led to a growing interest in the concept of , wherein the coagulation cascade and inflammatory responses are intricately linked, creating a prothrombotic and tumor-supportive environment.
View Article and Find Full Text PDFBMC Geriatr
September 2025
Department of Motor Behavior and Sport Management, Faculty of Sports Science, Urmia University, Urmia, Iran.
Background: Knee osteoarthritis (KOA) is a prevalent condition among older adults, leading to impaired proprioception and reduced gait speed, which compromise mobility and quality of life. While aquatic therapy and transcranial direct current stimulation (tDCS) have individually shown potential for enhancing motor and sensory functions, their combined effects are not well understood.
Objective: This study aimed to evaluate the combined effects of aquatic therapy and tDCS on knee proprioception and gait speed in older women with KOA.