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Myelomeningocele is a complex congenital defect that affects the spinal cord and structures associated with it. These patients often have neurogenic bowel and bladder dysfunction with constipation, fecal and urinary incontinence. In addition to dietary modifications, laxatives, and enemas, therapies such as biofeedback and neurostimulation (invasive and noninvasive) are sometimes used. These techniques are rarely available, may require surgical procedures, and are not devoid of complications. We present the case of a 13-year-old boy with myelomeningocele at the L4 level, with constipation, dyssynergic defecation, and fecal incontinence (FI). He was treated with biofeedback achieving partial improvement of FI, and then with transcutaneous electrical neurostimulation (TENS) with subsequent resolution of constipation and FI. To our knowledge, this is the first case report using neurostimulation with TENS applied to the S2-S4 dermatomes in a patient with myelomeningocele. This represents a safe, noninvasive, and low-cost treatment for these patients.
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http://dx.doi.org/10.1002/jpr3.12152 | DOI Listing |
Tidsskr Nor Laegeforen
September 2025
Nevrokirurgisk avdeling, Oslo universitetssykehus, Rikshospitalet, og, Pediatrisk nevrokirurgisk forskningsgruppe, Universitetet i Oslo.
Background: Closure of soft tissue defects following surgical repair of neonatal myelomeningocele requires prompt and well-justified decisions regarding the reconstruction method if the defects are to be closed within the first two days of life. For larger defects, flap reconstruction is often necessary. The aim of the study was to examine reconstruction methods for closing soft tissue defects following surgery for myelomeningocele, as well as complications and the need for reoperation.
View Article and Find Full Text PDFUltrasound Obstet Gynecol
September 2025
Maternal-Fetal Medicine Unit, Department of Obstetrics, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Objective: Fetoscopic repair for open neural tube defects (ONTDs) has gained acceptance among leading groups, although it remains controversial owing to the lack of a standardized neurosurgical technique. In 2018, our group described a new fetoscopic two-layer procedure with an exteriorized uterus for ONTD reconstruction. This study aimed to report obstetric, surgical and perinatal outcomes for the first 50 cases since the implementation of this technique and to provide comparative data with open fetal surgery studies.
View Article and Find Full Text PDFJ Surg Res
September 2025
Nationwide Children's Hospital, Abigail Wexner Research Institute, Columbus, Ohio; Department of Plastic and Reconstructive Surgery, Nationwide Children's Hospital, Columbus, Ohio; Pediatric Comprehensive Wound Program, Nationwide Children's Hospital, Columbus, Ohio. Electronic address: Jenny.Barker
Introduction: Chronic wounds affect approximately 10.5 million individuals annually in the United States. Although recent studies have highlighted a surge in chronic wound cases among younger populations, the collective burden of pediatric chronic wounds remains understudied.
View Article and Find Full Text PDFJ Clin Med
August 2025
Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
: Congenital anomalies impact 52 million infants worldwide with an estimated 94% living in low- and middle-income countries (LMICs). Approximately 200,000 children are born with a neural tube defect (NTD) in LMICs annually. Zambia is an LMIC with a high burden of myelomeningocele (MMC; a severe form of NTD).
View Article and Find Full Text PDFGenet Test Mol Biomarkers
August 2025
Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division, "Dr. Juan I. Menchaca" Civil Hospital of Guadalajara, Guadalajara, Mexico.
The nitric oxide (NO) synthase 3 () 894G>T (p.Glu298Asp) variant has been associated with an elevated risk of neural tube defects (NTDs) in Caucasians. This association suggests a link between the NO and folic acid pathways.
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