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PurposeTo evaluate anatomical and functional outcomes of Faricimab therapy on a case of polypoidal choroidal vasculopathy (PCV) refractory to previous treatments.Major findingsA 56-year-old patient with PCV presenting with a large pigment epithelial detachment (PED) showed best-corrected visual acuity (BCVA) improvement, subretinal fluid (SRF) reduction and PED height reduction at 2 months follow up after a loading phase of 4 monthly Faricimab injections. The patient had previously undergone Aflibercept, Brolucizumab and photodynamic therapy (PDT) treatments with a suboptimal response.ConclusionDespite Faricimab proving itself as an efficient alternative in a case of PCV poorly responsive to previous treatments, definite evidence still needs to be confirmed in larger studies.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012268 | PMC |
http://dx.doi.org/10.1177/11206721241310629 | DOI Listing |
Front Oncol
August 2025
Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Background: Anorectal malignant melanoma (ARMM) is an exceedingly rare and highly aggressive malignancy characterized by low prevalence, high misdiagnosis rates, and frequent recurrence/metastasis.
Case Report: This report details the case of a 51-year-old woman presenting with persistent bright red blood in her stool. Digital rectal examination revealed a firm, spherical mass approximately 4 cm from the anal verge.
Int J Surg Case Rep
August 2025
Department of Radiology, Faculty of Medicine and Health Science, Sana'a University, Sana'a City, Yemen.
Introduction: Malignant peripheral nerve sheath tumors (MPNSTs) are rare and aggressive soft tissue sarcomas. Its occurrence in the gastrointestinal tract, particularly in the sigmoid colon, is exceptionally uncommon and poses significant diagnostic and therapeutic challenges.
Case Presentation: We report the case of a 46-year-old female who presented with a four-year history of intermittent rectal bleeding and lower abdominal pain.
Cureus
July 2025
Department of Pathology, Government Medical College, Amritsar, Amritsar, IND.
Fibroepithelial stromal polyps (FEPs) or acrochordons of the breast nipple are seldom encountered benign tumors with mesoderm origin. These FEPs are frequently reported along the skin folds in the form of either skin-colored, tan, or hyperpigmented pedunculated or sessile papule-like or polypoidal growths. Three adult female patients presenting to a tertiary care hospital underwent surgical excision of nipple growth.
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July 2025
Pediatric Otolaryngology, Joe Dimaggio Children's Hospital, Hollywood, USA.
This case is that of a two-day-old male patient born full term with no pertinent history who presented with excess nasal secretions, feeding difficulty, respiratory distress, and hypoxemia requiring intubation. He was found to have an obstructive, polypoid mass in the nasopharynx on fiberoptic flexible laryngoscopy. Magnetic resonance imaging (MRI) of the brain and neck revealed an ovoid, circumscribed, peripherally enhancing mass in the posterior nasopharynx and oral cavity measuring 2.
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July 2025
Department of Hepatogastroenterology, Cheikh Zaid University Hospital, Rabat, MAR.
Ménétrier's disease (MD) is a rare hypertrophic gastropathy marked by enlarged gastric folds, excessive mucus secretion, and protein-losing enteropathy. We present the case of a 25-year-old man initially hospitalized with severe chronic anemia, which revealed a rare and challenging form of MD. The patient reported persistent epigastric pain, vomiting, and recurrent hematemesis.
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