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Article Abstract
Neural retina leucine zipper (NRL) is essential for the development of rods. The Nrl knockout (Nrl) mouse develops a cone-rich retina which facilitates investigations of cone biology. Previously, we identified the endoplasmic reticulum (ER) stress response gene ATF6 as a cause of cone dysfunction in people. Here, we investigated Atf6's influence on mouse cones in the cone-dominant Nrl mouse. We find that cone development appears unaffected, but the cone-dominant Nrl retina is highly vulnerable to ER stress-induced damage.
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