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The prevention and management of coal mine roof accidents remain challenging issues because it is difficult to evaluate and quantify the interaction effects of the disaster hazard factors objectively. This paper proposes a novel approach: combining information entropy and the surrogate model-and applies Sobol's method, aiming to solve it and to obtain the hazard factors' 1th and the global sensitivity value without human intervention. The results show that: (1) The complex logical relationships and interactions of roof hazard factors can be transformed into quantifiable numerical values by building a co-occurrence matrix of disaster factors and calculating its information entropy. (2) The sensitivity levels of roof hazard factors can be successfully distinguished and categorized into priority management and prevention or general management and prevention using the surrogate model and Sobol's sensitivity method. The novel sensitivity analysis approach suggested in this study considers both the individual impacts of hazard factors and their interactions, offering a more thorough framework for risk assessment as well as a fresh perspective and tool for coal mine safety research.
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http://dx.doi.org/10.1038/s41598-025-85988-y | DOI Listing |
Front Immunol
September 2025
Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.
Introduction: Human papillomavirus (HPV) infection has been implicated in autoimmune processes, yet concerns remain about the potential autoimmune risks of HPV vaccination. Juvenile idiopathic arthritis (JIA) is a chronic autoimmune condition that typically manifests in childhood. The relationship between HPV vaccination and the development of JIA remains uncertain.
View Article and Find Full Text PDFERJ Open Res
September 2025
Department of Bioanalysis, Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
Background: In Belgium, age-standardised hospital admission and mortality rates for asthma and COPD are higher than the European average. Understanding the factors that lead to a hospitalised exacerbation and/or mortality is needed to optimise patient management.
Methods: Patients ≥18 years old obtaining two claims for drugs for obstructive airway diseases (ATC code R03) in 1 year between 2017 and 2022 were identified in Belgian nationwide claims-based data.
Front Oncol
August 2025
Department of Surgery, Hebei Medical University, Shijiazhuang, Hebei, China.
Background: Tumor deposit (TD) is an independent risk factor associated with recurrence or metastasis for patients with colorectal cancer (CRC). The scenario in which both TD and lymph node metastasis (LNM) are positive is not clearly illustrated by the current TNM staging system. Simply treating one TD as one or two LNMs by a weighting factor is inappropriate.
View Article and Find Full Text PDFJTO Clin Res Rep
October 2025
Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden.
Introduction: Immune checkpoint blockade (ICB) is a standard first-line treatment for stage IV NSCLC without actionable oncogenic alterations. mutations, prevalent in 30% to 40% lung adenocarcinomas (LUAD) in Western populations, currently lack targeted first-line therapies. This study aimed to assess the predictive value of mutations for clinical outcomes after distinct ICB regimens, validating our previous findings in a larger cohort with extended follow-up.
View Article and Find Full Text PDFRes Pract Thromb Haemost
August 2025
Department of Cardiology, State Key Laboratory of Frigid Zone Cardiovascular Disease, General Hospital of Northern Theater Command, Shenyang, China.
Background: The selection of P2Y12 inhibitors for acute coronary syndrome patients after percutaneous coronary intervention (PCI) remains controversial among East Asian patients.
Objectives: This study aimed to identify the optimal P2Y12 inhibitor selection for the East Asian population carrying loss-of-function (LOF) alleles based on the Global Registry of Acute Coronary Events (GRACE) score.
Methods: Between March 2016 and March 2019, a cohort of 8683 patients diagnosed with acute coronary syndrome who survived PCI were enrolled in this study.