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http://dx.doi.org/10.3967/bes2024.179 | DOI Listing |
Metabolomics
September 2025
Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
Introduction: Knockout of the Fmo5 gene in mice led to a lean, slow-ageing phenotype characterised by the presence of 2,3-butanediol isomers in their urine and plasma. Oral treatment of wildtype mice with 2,3-butanediol led to a low cholesterol, low epididymal fat phenotype.
Objectives: Determine if significant, heterozygous coding variations in human FMO5 would give rise to similar clinical and metabolic phenotypes in humans, as in C57BL/6J mice with knockout of the Fmo5 gene and in particular, increased excretion of 2,3-butanediol.
Analyst
September 2025
Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
: Postmenopausal conditions can lead to metabolic disorders such as obesity and steatosis. (PT), a prominent traditional Chinese medicine, exerts potential therapeutic effects against hepatic injury. Nevertheless, the extent to which PT ameliorates liver damage resulting from estrogen deficiency, along with the associated mechanisms, remains poorly understood.
View Article and Find Full Text PDFAlzheimers Dement
September 2025
Cell Biology Program, Sloan Kettering Institute, New York, New York, USA.
Introduction: Biomarkers are essential for monitoring the progression of frontotemporal dementia (FTD). Although dysregulated brain lipid metabolism, particularly sphingolipids enriched in the nervous system, is a key feature of neurodegeneration, plasma lipids remain underexplored as biomarkers compared to imaging and serum proteins.
Methods: We examined plasma lipidomes using liquid chromatography-tandem mass spectrometry (LC-MS/MS) from individuals carrying pathogenic variants linked to autosomal dominant FTD (GRN, C9orf72, MAPT) and non-carriers.
Medicine (Baltimore)
September 2025
Laboratory Department of Laoshan Hospital, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, P.R. China.
Background And Objectives: The objective of this study was to investigate the changes in fecal microbial diversity and metabolic product levels in patients with stage IV colorectal cancer (CRC). The aim was to provide new research strategies for the diagnosis and treatment of CRC.
Methods: Fecal and blood samples were collected from both stage IV CRC patients and healthy individuals.
Food Res Int
November 2025
Tea Research Institution, Yunnan Academy of Agricultural Sciences, Kunming 650200, China; Yunnan Key Laboratory of Tea Science, Tea Research Institution, Yunnan Academy of Agricultural Sciences, Kunming 650200, China. Electronic address:
Pu-erh raw tea (PRT), a post-fermented tea, is prized for its complex flavor profile and health-promoting properties. While extended storage enhances its sensory attributes, the decade-scale metabolic dynamics underpinning flavor evolution remain unexplored. This study comprehensively characterized non-volatile metabolomic profiles and flavor changes in PRT across a 10-year storage period (2012-2023).
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