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Estimating 3D hand poses from monocular RGB images presents a series of challenges, including complex hand structures, self-occlusions, and depth ambiguities. Existing methods often fall short of capturing the long-distance dependencies of skeletal and non-skeletal connections for hand joints. To address these limitations, we introduce the Global Topology Interaction Graphormer Network (GTIGNet), a novel deep learning architecture designed to improve 3D hand pose estimation. Our model incorporates a Context-Aware Attention Block (CAAB) within the 2D pose estimator to enhance the extraction of multi-scale features, yielding more accurate 2D joint heatmaps to support the task that followed. Additionally, we introduce a High-Order Graphormer that explicitly and implicitly models the topological structure of hand joints, thereby enhancing feature interaction. Ablation studies confirm the effectiveness of our approach, and experimental results on four challenging datasets, Rendered Hand Dataset (RHD), Stereo Hand Pose Benchmark (STB), First-Person Hand Action Benchmark (FPHA), and FreiHAND Dataset, indicate that GTIGNet achieves state-of-the-art performance in 3D hand pose estimation. Notably, our model achieves an impressive Mean Per Joint Position Error (MPJPE) of 9.98 mm on RHD, 6.12 mm on STB, 11.15 mm on FPHA and 10.97 mm on FreiHAND.
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http://dx.doi.org/10.1016/j.neunet.2025.107221 | DOI Listing |
PLoS One
September 2025
Department of Health Services Research, and CAPHRI School for Public Health and Primary Care, Aging and Long Term Care Maastricht, Maastricht, the Netherlands.
Background: Older patients presenting with nonspecific complaints (NSC) in the Emergency Department (ED) pose diagnostic challenges. The lack of clear symptoms leads to high misdiagnosis rates, extended hospital stays, and functional impairment. However, limited research exists on diagnostic test utilization for this population.
View Article and Find Full Text PDFAppl Environ Microbiol
September 2025
Department of Food, Nutrition, and Packaging Sciences, Clemson University, Clemson, South Carolina, USA.
Disinfectant wipes are widely used to reduce microbial contamination on surfaces, yet there is limited information on how viruses are physically removed or chemically inactivated during wiping. This study aimed to address this gap by comparing the contributions of physical removal and chemical inactivation to overall disinfection efficacy. Glass and vinyl coupons were contaminated with SARS-CoV-2 surrogates, bovine coronavirus (BCoV), or human coronavirus OC43, at an initial titer of 5-6 log TCID/surface with 5% soil load.
View Article and Find Full Text PDFBioorg Chem
August 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, P.O. Box 11566, Abbassia, Cairo, Egypt. Electronic address:
Two series of triazolo[1,5-a]pyrimidines were designed and synthesized as antiproliferative agents targeting multi kinase inhibition aiming to increase potency and combat drug resistance. The synthesized compounds were tested for their antiproliferative activity. The triazolopyrimidine derivatives 9b, 9c, 12b and 12c showed promising anticancer activities, in particular, compounds 12b and 12c displayed broad spectrum antiproliferative potential against NCI cancer cell lines with GI mean value of 10.
View Article and Find Full Text PDFRev Sci Instrum
September 2025
Hefei University of Technology, School of Mechanical Engineering, Hefei 230009, China.
In unstructured environments, robots face challenges in efficiently and accurately grasping irregular, fragile objects. To address this, this paper introduces a soft robotic hand tailored for such settings and enhances You Only Look Once v5s (YOLOv5s), a lightweight detection algorithm, to achieve efficient grasping. A rapid pneumatic network-based soft finger structure, broadly applicable to various irregularly placed objects, is designed, with a mathematical model linking the bending angle of the fingers to input gas pressure, validated through simulations.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Department of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: Shoulder pain is a highly prevalent musculoskeletal disorder that severely compromises patients' quality of life. The Constant-Murley Scale (CMS) is a well-established method for shoulder function evaluation. However, the necessity of clinician involvement constrains its utility in continuous monitoring.
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