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We report a novel guanidine quinolinyl entatic state model system with an electron transfer rate on the order of 10 M s and remarkably little internal reorganization. Comparison between this system and previously reported TMGqu systems reveals an exponential correlation between the internal reorganization energy and the electron transfer rate.
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http://dx.doi.org/10.1039/d4cc06406b | DOI Listing |
PLoS Biol
September 2025
HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Neuropeptides play crucial roles in regulating context-dependent behaviors, but the underlying mechanisms remain elusive. We investigate the role of the neuropeptide SIFa and its receptor SIFaR in regulating two distinct mating duration behaviors in male Drosophila: Longer-Mating-Duration (LMD) and Shorter-Mating-Duration (SMD). We found that SIFaR expression in specific neurons is required for both LMD and SMD behaviors.
View Article and Find Full Text PDFDiabetes
September 2025
Division of Nephrology and the Einthoven Laboratory for Vascular and Regenerative Medicine. Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
This study provides a resource for kidney (cell type-specific) long noncoding (lnc)RNA expression and demonstrates the importance of lncRNAs in renal health. We identified 174 cell type-specific lncRNAs in the human kidney, with 54 showing altered expression in diabetic kidney disease. TCF21 antisense RNA inducing promoter demethylation (TARID), a podocyte-specific lncRNA upregulated in diabetic kidney disease, is crucial for actin cytoskeleton reorganization in podocytes.
View Article and Find Full Text PDFSci Rep
September 2025
Department of Earth and Planetary Sciences, ETH Zürich, Zürich, 8092, Switzerland.
The occurrence of tectonic plate reorganization events is evident throughout the geologic record and appears to be associated with the cessation of mature and/or initiation of new subduction. Subduction initiation that produced the bend in the Hawaii-Emperor seamount chain resulted in the most recent upheaval of plate motion and engendered dramatic changes in plate velocities. Here, applying a method for identifying plate boundaries in a numerical global mantle convection model, we calculate Euler vector time series of self-consistently generated plates over a period of approximately 144 Myr.
View Article and Find Full Text PDFMedComm (2020)
September 2025
Radiation therapy is a fundamental component of cancer treatment, benefiting 50%-70% of patients by selectively targeting malignant tissues. However, radioresistance remains a significant challenge, often driven by epithelial-mesenchymal transition (EMT). EMT increases cancer invasiveness and metastasis by upregulating mesenchymal markers, including vimentin and N-cadherin, and downregulating epithelial markers, such as E-cadherin.
View Article and Find Full Text PDFPhysiol Plant
September 2025
State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, China.
Climate-driven abiotic stresses, responsible for approximately 50% of global crop yield losses, are putting agriculture under increasing pressure, demanding smarter ways to strengthen plants' natural defenses beyond genetic modification. Hydrogen peroxide (HO), long recognized as a key signaling molecule, plays a powerful role in helping plants cope with environmental stress. This review deciphers the mechanistic basis of HO-mediated capacity enhancement under diverse stresses (drought, salinity, heavy metals, heat, cold) while also addressing climate-intensified challenges like waterlogging and ultraviolet (UV) radiation.
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