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Observational evidence strongly supports the existence of a Super Massive Black Hole at the Galactic center, surrounded by dense stellar clusters. Modeling galactic centers with intricate structures like shells and rings pose challenges, prompting the use of simplified models such as a spherical monopole potential with a multipolar halo mass distribution. This approach, employing a multipolar expansion model, provides versatility for numerical analyses, revealing the complex dynamics of stars in this region. Pseudopotentials like Paczynsky-Wiita and Artemova-Bjornsson-Novikov are utilized to simulate the impacts of strong gravity from nonrotating and rotating compact objects respectively, elucidating their influence on stellar dynamics. Chaos naturally arises due to noncentral forces, visualized using the Poincaré section technique. Of particular importance is the utilization of the Smaller Alignment Index (SALI), a powerful nonlinear dynamical tool, which categorizes particle orbits as escaping, regular, sticky, or chaotic. We exhaustively examine all combinations of multipolar moments up to the octupolar term along with spin using this tool, which had not been studied earlier. SALI provides a straightforward yet efficient method for assessing the interplay between the system's different multipolar moments, their combinations, and spin. Thus, our findings offer insights into the dynamics of compact objects enshrouded in a halo mass distribution and lay the groundwork for understanding complex astrophysical systems in galactic centers.
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http://dx.doi.org/10.1103/PhysRevE.110.064202 | DOI Listing |
Phys Rev E
December 2024
Department of Physics, 30, Mother Teresa Sarani Kolkata-700016, India.
Observational evidence strongly supports the existence of a Super Massive Black Hole at the Galactic center, surrounded by dense stellar clusters. Modeling galactic centers with intricate structures like shells and rings pose challenges, prompting the use of simplified models such as a spherical monopole potential with a multipolar halo mass distribution. This approach, employing a multipolar expansion model, provides versatility for numerical analyses, revealing the complex dynamics of stars in this region.
View Article and Find Full Text PDFJ ECT
August 2024
From the Division of Neuropsychiatry and Neuromodulation, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Attempts to dissociate electroconvulsive therapy (ECT) therapeutic efficacy from cognitive side effects of ECT include modifying electrode placement, but traditional electrode placements employing 2 large electrodes are inherently nonfocal, limiting the ability to selectively engage targets associated with clinical benefit while avoiding nontargets associated with adverse side effects. Limited focality represents a technical limitation of conventional ECT, and there is growing evidence that the spatial distribution of the ECT electric fields induced in the brain drives efficacy and side effects. Computational models can be used to predict brain current flow patterns for existing and novel ECT montages.
View Article and Find Full Text PDFMol Biol Cell
February 2024
Cell and Developmental Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Myosin 10 (Myo10) couples microtubules and integrin-based adhesions to movement along actin filaments via its microtubule-binding MyTH4 domain and integrin-binding FERM domain, respectively. Here we show that Myo10-depleted HeLa cells and mouse embryo fibroblasts (MEFs) both exhibit a pronounced increase in the frequency of multipolar spindles. Staining of unsynchronized metaphase cells showed that the primary driver of spindle multipolarity in Myo10-depleted MEFs and in Myo10-depleted HeLa cells lacking supernumerary centrosomes is pericentriolar material (PCM) fragmentation, which creates y-tubulin-positive acentriolar foci that serve as extra spindle poles.
View Article and Find Full Text PDFbioRxiv
June 2023
Cell and Developmental Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
Myosin 10 (Myo10) has the ability to link actin filaments to integrin-based adhesions and to microtubules by virtue of its integrin-binding FERM domain and microtubule-binding MyTH4 domain, respectively. Here we used Myo10 knockout cells to define Myo10's contribution to the maintenance of spindle bipolarity, and complementation to quantitate the relative contributions of its MyTH4 and FERM domains. Myo10 knockout HeLa cells and mouse embryo fibroblasts (MEFs) both exhibit a pronounced increase in the frequency of multipolar spindles.
View Article and Find Full Text PDFJ Chem Neuroanat
March 2021
Universidade do Estado do Rio Grande do Norte, Brazil.
The location and distribution of the calcium-binding protein calbindin-D28k (CB) has been considered to be of great value as a neuronal marker for identifying distinct brain regions and discrete neuronal populations. In the amygdaloid complex (AC), the balance of excitatory and inhibitory inputs is controlled by CB immunoreactive interneurons. Alterations of inhibitory mechanisms in the AC may play a role in the emotional symptomatology of neurological diseases like Alzheimer's and psychiatric disorders like posttraumatic stress disorder.
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