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The growing integration of urban air mobility (UAM) for urban transportation and delivery has accelerated due to increasing traffic congestion and its environmental and economic repercussions. Efficiently managing the anticipated high-density air traffic in cities is critical to ensure safe and effective operations. In this study, we propose a routing and scheduling framework to address the needs of a large fleet of UAM vehicles operating in urban areas. Using mathematical optimization techniques, we plan efficient and deconflicted routes for a fleet of vehicles. Formulating route planning as a maximum weighted independent set problem enables us to utilize various algorithms and specialized optimization hardware, such as quantum annealers, which has seen substantial progress in recent years. Our method is validated using a traffic management simulator tailored for the airspace in Singapore. Our approach enhances airspace utilization by distributing traffic throughout a region. This study broadens the potential applications of optimization techniques in UAM traffic management.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799414 | PMC |
http://dx.doi.org/10.1038/s41598-025-86843-w | DOI Listing |
HCMOP are widespread in practical engineering such as vehicle routing problem and shop scheduling problem etc. The problems introduced above refer to optimization problems with complex constraints which lead to small and disconnected feasible regions. The optimization performance of general evolutionary algorithms decreases due to the small and dispersed feasible regions in highly constrained optimization problems.
View Article and Find Full Text PDFJ Proteomics
July 2025
Laboratory for Structural and Computational Proteomics, Carlos Chagas Institute, Fiocruz-Parana, Brazil; Integrated Space Stem Cell Orbital Research (ISSCOR) Center, University of California San Diego, CA, USA. Electronic address:
We present Q2C, an open-source software designed to streamline mass spectrometer queue management and assess performance based on quality control metrics. Q2C provides a fast and user-friendly interface to visualize projects queues, manage analysis schedules and keep track of samples that were already processed. Our software includes analytical tools to ensure equipment calibration and provides comprehensive log documentation for machine maintenance, enhancing operational efficiency and reliability.
View Article and Find Full Text PDFSci Rep
July 2025
School of Computer Engineering, Hubei University of Arts and Science, Xiangyang, 441053, China.
By integrating electric vehicles (EVs), the multi-microgrids (MMGs) can significantly enhance their resilient operation capabilities. However, existing works face challenges in formulating optimal routing and scheduling strategies for EVs, due to the spatial-temporal uncertainty of the distribution and transportation networks, as well as incomplete information. This paper addresses the coordination problem of EVs for the resilience enhancement of MMGs, using a distributed multi-agent deep reinforcement learning approach to minimize the load-shedding cost.
View Article and Find Full Text PDFCent Eur J Oper Res
March 2025
University of Primorska, Titov trg 4, 6000 Koper, Slovenia.
The management of truck arrivals at container terminals is crucial for efficient port operations. Congestions developing both outside and inside the gates can cause logistical problems, while also having a significant impact on the environment and the surroundings of the port. Therefore, optimizing truck queues outside the gates of the port, as well as routing of trucks inside the terminals can lead to an improvement in the overall efficiency of the port processes.
View Article and Find Full Text PDFMicromachines (Basel)
May 2025
School of Big Data, Fuzhou University of International Studies and Trade, Fuzhou 350202, China.
Routing and application mapping are critical stages in the design of continuous-flow microfluidic biochips (CFMBs). The routing stage determines the channel network connecting components and ports, while application mapping schedules fluid transportation and wash operations based on the designed biochip architecture. Existing methods typically handle these stages separately: routing focuses solely on physical metrics without considering subsequent scheduling requirements, while application mapping adopts one-shot scheduling strategies that can lead to suboptimal solutions.
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