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Recent years have witnessed tremendous advances in wearable sensors, which play an essential role in personalized healthcare for their ability for real-time sensing and detection of human health information. Nanozymes, capable of mimicking the functions of natural enzymes and addressing their limitations, possess unique advantages such as structural stability, low cost, and ease of mass production, making them particularly beneficial for constructing recognition units in wearable biosensors. In this review, we aim to delineate the latest advancements in nanozymes for the development of wearable biosensors, focusing on key developments in nanozyme immobilization strategies, detection technologies, and biomedical applications. The review also highlights the current challenges and future perspectives. Ultimately, it aims to provide insights for future research endeavors in this rapidly evolving area.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791255 | PMC |
http://dx.doi.org/10.1016/j.isci.2025.111763 | DOI Listing |
Mikrochim Acta
September 2025
Faculty of Science, Shenyang University of Chemical Technology, Shenyang, 110142, China.
A sensitive electrochemical glucose biosensor using ZrO₂@CNTs nanocomposite was developed for real-time metabolism monitoring for athletes. The nanocomposite was prepared by a simple ultrasound-assisted technique, and the glucose oxidase (GOx) was covalently immobilized to improve the biorecognition ability. CNTs treated with acid served as a highly conductive framework, and ZrO₂ nanoparticles can provide structural stability and catalytic performance, thus showing synergistic enhancement of electron transfer kinetics and enzyme loading capacity.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
Manta Pharma LLC, Gaithersburg, MD, United States. Electronic address:
Biosensing technologies, including wearables, ingestibles, and implantables, are transforming modern healthcare by enabling real-time monitoring and precise personalized treatment. As these technologies advance, ensuring their safety, efficacy, and ethical deployment remains paramount. This chapter explores the regulatory framework that governs biosensing devices in the United States, detailing premarket approval pathways, postmarket surveillance, and emerging regulatory incentives that balance innovation with patient protection.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
School of Applied Sciences and Technology, Gujarat Technological University, Gujarat, India. Electronic address:
This chapter examines advancements and future trajectories in wearable biosensing technologies, a multidisciplinary field encompassing healthcare, materials science, and information technology. Wearable biosensors are revolutionizing real-time physiological and biochemical monitoring with applications in personalized health monitoring, disease diagnosis, fitness, and therapeutic interventions. In addition to Internet of Things (IoT) and wireless connectivity technologies such as Bluetooth Low Energy (BLE) and 5G, which facilitate transparent remote monitoring and data exchange, other notable innovations such as machine learning and artificial intelligence enhance real-time processing of data, predictive analytics, and personalized healthcare solutions.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
Department of Information Sciences and Technology, School of Computing, George Mason University, Fairfax, VA, United States.
Data gathering for diagnostic purposes often relies on psychological instruments and validated tests applied individually through in person interviews. Such an approach is limited since it relies on a subjective perception of the individual as well as their abilities to recall information concerning their behaviors, thoughts, and feelings. Thus, the accuracy of the assessment tends to be unreliable and prone to bias, stigma, as well as subjective interpretations.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
Division of Sleep Medicine, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, United States; Division of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, United States; Department of Medicine, Case Western Reserve University, Clevelan
Obstructive sleep apnea (OSA) is a pervasive disorder characterized by recurrent airway obstructions during sleep. OSA carries serious health risks, such as cardiovascular and cognitive impairments, and imposes a significant economic burden. This chapter provides a comprehensive overview of various biosensors currently employed for OSA detection, including in-lab polysomnography and flow-based home sleep apnea testing.
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