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| http://dx.doi.org/10.1016/j.jcjo.2024.12.008 | DOI Listing |
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Background: Perioperative neurocognitive disorders (PND) is a significant clinical syndrome and neuroinflammation is an important pathological process. Matrix metalloproteinase 9 (MMP9) as a Zn2+-dependent matrix enzyme, not only maintains the integrity of the blood-brain barrier and synaptic plasticity, but also plays a key regulatory factor in peripheral and central nervous inflammation. This study aimed to investigate the effects of MMP9-mediated microglial polarization on surgery-induced neuroinflammation in aged rats and to provide novel targets for prevention and treatment of PND.
View Article and Find Full Text PDFToward a Genetic Signature of Resistance to Activity-Based Anorexia in Striatal Projecting Cortical Neurons.
Int J Eat Disord
September 2025
Department of Physiology, Monash University, Clayton, Victoria, Australia.
Objective: Converging evidence from neuroimaging studies and genome-wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology of anorexia nervosa (AN). However, identifying the causal role of circuit-specific genes in the development of the AN-like phenotype remains challenging and requires the combination of novel molecular tools and preclinical models.
Methods: We used the activity-based anorexia (ABA) rat model in combination with a novel viral-based translating ribosome affinity purification (TRAP) technique to identify transcriptional differences within a specific neural pathway that we have previously demonstrated to mediate pathological weight loss in ABA rats (i.
Vagus Nerve Stimulation Attenuates Cognitive Impairment in Traumatic Brain Injury via the mtDNA/cGAS-STING/NLRP3 Inflammasome Axis.
Neurocrit Care
September 2025
Department of Rehabilitation, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Background: Traumatic brain injury (TBI) is a major life-threatening event. In addition to neurological deficits, it can lead to long-term impairments of cognitive function. The vagus nerve (VN) provides a direct communication conduit between the central nervous system and the periphery, and modulation of the inflammatory reflex via electrical stimulation of the vagus nerve (VNS) shows efficacy in ameliorating pathology in neurodegenerative diseases.
View Article and Find Full Text PDFToward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates.
J Nucl Med
September 2025
PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
The main inhibitory neurotransmitter in the central nervous system is γ-aminobutyric acid (GABA). GABA transporter type 1 (GAT-1) is the principal GABA transporter in the brain, and it plays a crucial role in modulating GABA signaling. Its potential role in several neuropsychiatric disorders makes it an important target to study.
View Article and Find Full Text PDFNutritional co-therapy with vitamin D and L-theanine reduces unpredictable mild chronic stress (UCMS) in aged mice by restoring alpha-oscillations, dopamine levels and behavioral improvement.
Exp Gerontol
September 2025
Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan. Electronic address:
Late-life depression (LLD) arises from the confluence of neurochemical dysfunction, oxidative stress, and neural network disintegration, presenting a formidable therapeutic challenge. Here, we demonstrated that combined vitamin D (Vit D) and L-theanine (L-thea) administration exerts multimodal neurorestorative effects in an aged murine model of unpredictable chronic mild stress (UCMS), addressing the core triad of LLD pathology: dopaminergic decline, redox imbalance, and thalamocortical dyssynchrony. Using a comprehensive battery of behavioral assays (Open Field Test, Elevated Plus Maze, Hole Board Test, Tail Suspension Test, Forced Swim Test, Sucrose Preference Test), we observed profound anxiogenic and anhedonic phenotypes in the UCMS-exposed mice, accompanied by elevated immobility and suppressed exploratory drive.
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