Advanced Artificial-Intelligence-Based Jiang Formula for Intraocular Lens Power in Congenital Ectopia Lentis.

Purpose: The purpose of this study was to develop an artificial intelligence (AI)-based intraocular lens (IOLs) power calculation formula for improving the accuracy of IOLs power calculations in patients with congenital ectopia lentis (CEL).

Methods: A total of 651 eyes with CEL that underwent IOLs implantation surgery were included in this study. An AI-based ensemble formula-the Jiang Formula, was developed using a training dataset of 520 eyes and evaluated on a testing dataset of 131 eyes. A five-fold cross-validation and a two-layer ensemble learning model were constructed. The formula was then tested in a test set and compared against five current classic formulas.

Results: The cohort included young patients (mean age = 14.38 ± 13.35 years). The Jiang Formula showed the lowest prediction error (PE; = 0.08 ± 1.01 diopters [D]), absolute error (AE; = 0.77 ± 0.65 D), median absolute error (MedAE; = 0.66 D), and root mean square error (RMSE; = 1.02 D) among six formulas (P < 0.001). Moreover, 68.00% of the eyes in the test set had AE within 1.0 D in the Jiang Formula.

Conclusions: AI-integrated two-layer ensemble learning model demonstrates promising applications in IOLs power calculations for patients with CEL, not only providing higher predictive accuracy than current classic formulas but also accommodating extreme values and variations in surgical techniques.

Translational Relevance: The Jiang Formula, an AI-integrated two-layer ensemble learning model, enhances IOLs power calculation accuracy in patients with CEL, ultimately improving surgical outcomes and supporting more effective, personalized treatment in this unique patient group.