Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Driven by our recent medicinal chemistry research, we have investigated the coupling reaction between aliphatic -hydroxyphthalimide esters and terminal 2-trifluoromethylalkenes. This reaction was driven by the photochemical activity of the electron donor-acceptor (EDA) complex. The reaction's efficiency hinges on the olefin's electronic effect, with electron-withdrawing groups yielding much better results. Furthermore, this reaction is also applicable to trifluoromethyl alkyl alkenes, enabling the synthesis of target products in moderate yields. By employing this method, we successfully synthesized a series of bioactive molecules, among which compounds 3k, 3l and 3m demonstrated robust antitumor activity against both A549 and SK-hep-1 cancer cell lines.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4ob01950d | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ultrafast Correlation Energy Estimator.
J Phys Chem A
September 2025
Institute of Physics, Faculty of Physics, Astronomy, and Informatics, Nicolaus Copernicus University in Toruń, ul. Grudzia̧dzka 5, 87-100 Toruń, Poland.
A virtually no-cost method is proposed that can compute the correlation energies of general, covalently bonded, organic, and inorganic molecules (including conjugated π-electron systems) with a well-defined dominant Lewis structure at the accuracy of 99.5% of the near-exact values determined by the coupled-cluster singles, doubles, and perturbative triples [CCSD(T)] in the complete-basis-set (CBS) limit. This Correlation Energy Per Bond (CEPB) method assigns a partial correlation energy to each bond type (characterized by the identities of the two atoms forming the bond and its integer bond order) and to a lone pair, regardless of the bond length, bond angle, sp-hybridization, π-electron conjugation, ionicity, noncovalent interactions, etc.
View Article and Find Full Text PDFTowards durable photocatalytic seawater splitting: design strategies and challenges.
Chem Commun (Camb)
September 2025
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing & State Key Laboratory of Silicate Materials for Architectures & School of Chemistry, Chemical Engineering and Life Sciences & School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070
Photocatalytic seawater splitting (PSWS), which utilizes abundant solar and ocean resources, is one of the most promising technologies for sustainable hydrogen production. However, the complex composition of seawater significantly limits the durability and activity of photocatalysts. In this review, we first identify the primary factors that contribute to photocatalyst deactivation during PSWS, including chloride induced corrosion and loss of active sites, and light shielding caused by precipitation of metal cation salts.
View Article and Find Full Text PDFMedium Effect of Bicontinuous Microemulsion on Cobaltocene-Mediated Electroreduction of Coenzyme NAD.
Langmuir
September 2025
Key Laboratory of Colloid and Interface Chemistry of the Education Ministry of China, Shandong University, Jinan 250100, China.
In this paper, a phosphate buffer (0.10 M, pH 7.5)--hexadecane bicontinuous microemulsion (BME) stabilized by the nonionic surfactant CE was for the first time used as the medium to investigate its effect on the electrochemical behavior of the cobaltocene redox couple ( (III)/ (II)) as electron mediator and the -mediated electroreduction of coenzyme NAD.
View Article and Find Full Text PDFThioesterification of Polyfluoroarenes via Copper-Catalyzed Radical Cross-Coupling with KS and Aldehydes in Water.
Org Lett
September 2025
College of Materials and Chemical Engineering, Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, China Three Gorges University, Yichang, Hubei 443002, P. R. China.
A novel copper-catalyzed radical cross-coupling reaction for the thioesterification of polyfluoroarenes is developed using KS and aldehydes in water. This protocol employs a readily available KS as a sulfur source, eliminating the need for hazardous thiols and organic solvents. The mild reaction conditions are compatible with a wide range of functional groups, providing access to diverse polyfluoroaryl thioesters.
View Article and Find Full Text PDFElectronegativity-Induced Jahn-Teller Distortion Boosts Li-S Conversion on Asymmetric Cu Single-Atom Catalysts.
J Phys Chem A
September 2025
Department of Chemistry, Tsinghua University, Beijing 100084, China.
A series of Cu-based single-atom catalysts (SACs) with asymmetric coordination were designed to accelerate lithium-sulfur (Li-S) chemistry. The electronegativity contrast from the dopant induces a localized electronic asymmetry that amplifies Jahn-Teller distortion at the Cu center. This distortion profoundly modulates the Cu 3d electronic structure and its interaction with Li-S intermediates.
View Article and Find Full Text PDF