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Article Abstract
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| http://dx.doi.org/10.1038/s41477-025-01926-w | DOI Listing |
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Article Synopsis
- Pseudouridine (Ψ) is a common RNA modification found in small RNAs and mRNAs, but its functions and distribution, especially in mRNAs, are not well understood.
- A new model called PseudoUridyLation Site Estimator (PULSE) uses a convolutional neural network to analyze Ψ sites and learn patterns from RNA sequences.
- PULSE has been tested extensively and outperforms existing methods, allowing researchers to better understand the roles of pseudouridylation in RNA structure, translation, and stability.