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The five-paced viper (Deinagkistrodon acutus) is a prevalent venomous snake in China. Its venom comprises metalloproteinases, phospholipase A2, C-type lectin-like proteins, and serine proteases, which can induce acute reactions such as tissue inflammation, edema, necrosis, hemorrhage, coagulopathy, and even multiple organ failure. This report details a case involving a child in a rural area of China who was accidentally bitten by Deinagkistrodon acutus while playing outdoors and subsequently died despite treatment. The autopsy findings and histopathological results may assist in the clinical management and forensic practice related to Deinagkistrodon acutus envenomation in the future.
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http://dx.doi.org/10.1016/j.legalmed.2025.102590 | DOI Listing |
J Venom Anim Toxins Incl Trop Dis
September 2025
Department of Emergency, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, China.
Background: Inflammation plays a critical role in the pathogenesis of limb injury caused by snakebite. Investigating its regulatory mechanisms and intervention strategies may help identify effective treatments. Recent studies have shown that pyroptosis exacerbates organ damage by amplifying inflammatory responses.
View Article and Find Full Text PDFJ Appl Toxicol
September 2025
Nanhua Hospital Affiliated to University of South China, Hengyang, Hunan, China.
The Deinagkistrodon acutus is the most widely distributed venomous snake in China, and its clinical manifestations are primarily characterized by hemorrhage and coagulation disorders. Previous studies have suggested that mesenteric vascular injury induced by Deinagkistrodon acutus venom may be the primary cause of hemorrhage in envenomation. Protease-activated receptor 1 (PAR1) is highly expressed in vascular tissues and plays an important role in regulating the structure and function of blood vessels.
View Article and Find Full Text PDFSci Rep
July 2025
Department of Emergency Medicine, Fifth Affiliated Hospital (Lishui Central Hospital), Wenzhou University School of Medicine, Lishui, China, 323000.
Deinagkistrodon acutus is one of the unique venomous snakes native to Southeast Asia. Limb injury caused by this species is the main cause of disability in snake bite patients, while the relevant pathogenesis mechanism and intervention strategies need to be further explored. In recent years, studies have established that mesenchymal stem cell-derived exosome (MSC-Exo) exerts a positive therapeutic effect on reducing limb injuries caused by a variety of factors, but this effect in limb injuries caused by snake bite is still unclear.
View Article and Find Full Text PDFJ Venom Anim Toxins Incl Trop Dis
May 2025
Engineering Research Center of Active Substance and Biotechnology, Ministry of Education, College of Life Science, Chongqing Normal University, Chongqing, China.
Background: , or the hundred-pace snake, poses severe health risks due to its venom. Envenomation by this snake leads to complications such as hemorrhage, edema, and coagulopathy. Traditional antivenoms are limited by venom variability and often contain non-neutralizing antibodies, highlighting the need for more precise and effective immunogens.
View Article and Find Full Text PDFClin Toxicol (Phila)
March 2025
The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Introduction: Antivenom treatment is the specific treatment for envenomation. However, safety concerns regarding the use of antivenom in this population have been reported only infrequently in the literature. We aimed to determine the incidence of anaphylactic reactions and serum sickness following antivenom administration in a cohort of patients envenomed by .
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