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Privacy is as a critical issue in the age of data. Organizations and corporations who publicly share their data always have a major concern that their sensitive information may be leaked or extracted by rivals or attackers using data miners. High-utility itemset mining (HUIM) is an extension to frequent itemset mining (FIM) which deals with business data in the form of transaction databases, data that is also in danger of being stolen. To deal with this, a number of privacy-preserving data mining (PPDM) techniques have been introduced. An important topic in PPDM in the recent years is privacy-preserving utility mining (PPUM). The goal of PPUM is to protect the sensitive information, such as sensitive high-utility itemsets, in transaction databases, and make them undiscoverable for data mining techniques. However, available PPUM methods do not consider the generalization of items in databases (categories, classes, groups, etc.). These algorithms only consider the items at a specialized level, leaving the item combinations at a higher level vulnerable to attacks. The insights gained from higher abstraction levels are somewhat more valuable than those from lower levels since they contain the outlines of the data. To address this issue, this work suggests two PPUM algorithms, namely MLHProtector and FMLHProtector, to operate at all abstraction levels in a transaction database to protect them from data mining algorithms. Empirical experiments showed that both algorithms successfully protect the itemsets from being compromised by attackers.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790145 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0317427 | PLOS |
Proc Natl Acad Sci U S A
September 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug De
Proliferative retinopathy is a leading cause of irreversible blindness in humans; however, the molecular mechanisms behind the immune cell-mediated retinal angiogenesis remain poorly elucidated. Here, using single-cell RNA sequencing in an oxygen-induced retinopathy (OIR) model, we identified an enrichment of sorting nexin (SNX)-related pathways, with SNX3, a member of the SNX family that is involved in endosomal sorting and trafficking, being significantly upregulated in the myeloid cell subpopulations of OIR retinas. Immunostaining showed that SNX3 expression is markedly increased in the retinal microglia/macrophages of mice with OIR, which is mainly located within and around the neovascular tufts.
View Article and Find Full Text PDFAppl Biochem Biotechnol
September 2025
School of Biological Sciences, University of the Punjab, Quaid-E-Azam Campus, P.O. 54590, Lahore, Pakistan.
Recombinant DNA technology is widely used to produce industrially and pharmaceutically important proteins. In silico analysis, performed before executing wet lab experiments has been greatly helpful in this connection. A shift in protein analysis has been observed over the past decade, driven by advancements in bioinformatics databases, tools, software, and web servers.
View Article and Find Full Text PDFJ Agric Food Chem
September 2025
School of Food & Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013 Jiangsu Province, China.
Pectinases are indispensable biocatalysts for pectin degradation in food and bioprocessing industries, yet natural enzymes often lack tailored functionalities for modern applications. While a previous review discussed pectinases in terms of production and application, this review particularly discusses an integrated framework for robust pectinases. This framework combines enzyme mining, protein engineering, and AI-assisted design to systematically discover, optimize, and customize pectinases.
View Article and Find Full Text PDFJAMIA Open
October 2025
Division of Pulmonary and Critical Care, Brigham and Women's Hospital, Boston, MA, United States.
Objectives: Unstructured data, such as procedure notes, contain valuable medical information that is frequently underutilized due to the labor-intensive nature of data extraction. This study aims to develop a generative artificial intelligence (GenAI) pipeline using an open-source Large Language Model (LLM) with built-in guardrails and a retry mechanism to extract data from unstructured right heart catheterization (RHC) notes while minimizing errors, including hallucinations.
Materials And Methods: A total of 220 RHC notes were randomly selected for pipeline development and 200 for validation from the Pulmonary Vascular Disease Registry.
Dialogues Health
December 2025
Department of Health, Aging & Society, McMaster University, Hamilton, Canada.
Introduction: Access to water, sanitation, and hygiene (WASH) is critical for public health but remains inadequate in marginalized areas, particularly in sub-Saharan Africa's artisanal and small-scale mining (ASM) communities. Adolescent girls and young women (AGYW) in these settings face unique challenges that impact their health and wellbeing.
Objective: This study aimed to assess WASH access among adolescent girls and young women (aged 10-24) in last-mile ASM communities in Ghana and Uganda, identifying disparities and factors influencing access.