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Although sarcoid-like reactions are uncommon in colorectal cancer, they can coexist with other cancers. We herein report a 50-year-old woman with sigmoid adenocarcinoma and osseous sarcoid-like reactions that resembled metastases. Positron emission tomography-computed tomography revealed an uptake in the iliac bone and para-aortic lymph nodes. The depth of invasion indicates non-metastatic lesions. Bone and lymph node biopsies revealed epithelioid non-caseating granulomas with bone trabeculae, resulting in a final diagnosis of pathological T2N2aM0, Stage IIIB. When the expected depth of invasion differs from that of typical bone metastases, colorectal cancer-associated bone lesions should be evaluated for sarcoid-like reactions.
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http://dx.doi.org/10.2169/internalmedicine.4761-24 | DOI Listing |
Clin Nucl Med
October 2025
Nuclear Medicine, Emory University Hospital, Atlanta, GA.
Drug-induced sarcoid-like reactions (DISRs) present complex challenges in clinical management. The most common presentation in FDG-PET/CT scan is bilateral symmetrical lymphadenopathy, and occasionally spleen and bone involvement. DISR presenting as fasciitis/ myofasciitis is extremely rare.
View Article and Find Full Text PDFKidney Int Rep
August 2025
Division of Nephrology and Hypertension, University of Minnesota, Minneapolis, Minnesota, USA.
J Neurosurg Case Lessons
July 2025
Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Background: Accumulation of normal lymphocytes within the intradural extramedullary space is rare. To the best of the authors' knowledge, no prior reports have described a sarcoid-like reaction with lymphoid infiltration arising around the jugular foramen and adhering to cranial nerves. Here, the authors present the case of a tumor-mimicking sarcoid-like reaction with intracranial extension from the left jugular foramen, adherent to the cerebellum, medulla oblongata, and lower cranial nerves.
View Article and Find Full Text PDFClin Exp Dermatol
July 2025
Department of Stomatology, São Paulo University, São Paulo, SP, Brazil.
Mucocutaneous reactions are among the most frequent and earliest immune-related adverse events (irAEs) secondary to programmed cell death protein 1 (PD-1) inhibitors treatment, often resembling autoimmune or immune-mediated disorders. Despite their prevalence, biopsies of irAEs are infrequently performed, resulting in limited data on their histopathological and immunohistochemical findings. We evaluated the histopathological and immunohistochemical features of irAEs in seven cancer patients treated with pembrolizumab (n = 5) or nivolumab (n = 2).
View Article and Find Full Text PDFCase Rep Oncol Med
July 2025
Department of Medical Oncology, Jessa Ziekenhuis, Hasselt, Belgium.
Hypercalcemia of malignancy is a well-known phenomenon in cancer patients, often associated with poor prognosis. The discovery of immune checkpoint inhibitors has revolutionised cancer therapy by improving prognosis in numerous different cancer types. Unfortunately, immune-related adverse events frequently arise, particularly with dual checkpoint inhibition.
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