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http://dx.doi.org/10.1016/j.healun.2025.01.015 | DOI Listing |
Am J Prev Cardiol
September 2025
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA.
Background: In adults without cardiovascular disease (CVD), there is limited understanding of the association between overall cardiovascular health (CVH) and arterial health.
Methods: In 2330 Framingham Heart Study Offspring participants free of CVD (60±9 years; 57% women) with Life's Essential 8 (LE8) and applanation tonometry data (Exam 7), we calculated CVH scores per American Heart Association's LE8 guidelines. Multivariable-adjusted regression analyses examined the relations of LE8 with aortic stiffness and pressure pulsatility [negative inverse carotid-femoral pulse wave velocity (niCFPWV), central pulse pressure (CPP), respectively], and examined effect modification by age and sex.
Phytomedicine
August 2025
Cardiology Department, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China. Electronic address:
Background: Atherosclerosis (AS) is a leading risk factor for cardiovascular diseases globally, characterised by the accumulation of lipids and cholesterol in arterial walls, causing vascular narrowing and sclerosis along with chronic inflammation; this leads to increased risk of heart disease and stroke, significantly impacting patients' health. Danxia Tiaoban Decoction (DXTB), a traditional Chinese medicine (TCM) formula, has demonstrated positive clinical effects in treating AS; however, its mechanisms of action remain unclear.
Objective: To explore the potential mechanisms of action of DXTB in treating AS through multi-omics integration and experimental validation.
Brain Behav
September 2025
School of Public Health, Shandong Second Medical University, Weifang, Shandong, China.
Purpose: Stroke has a high mortality and disability rate, yet its underlying mechanisms remain not fully understood. The occurrence of stroke is influenced by a combination of environmental factors, genetic factors, and their interaction, making its pathophysiology very intricate.
Finding: With the development of genetic technology, researchers are endeavoring to explore the genetic risks of stroke from various perspectives, including genomics, transcriptomics, proteomics, and epigenetics, beyond common risk factors such as hypertension, diabetes, and heart disease.
Int J Cardiol
August 2025
Université de Lorraine, Centre d'Investigations Cliniques Plurithématique 1433 and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.. Electronic address:
Chem Biomed Imaging
August 2025
School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Accurate and automated segmentation of 3D biomedical images is a sophisticated imperative in clinical diagnosis, imaging-guided surgery, and prognosis judgment. Although the burgeoning of deep learning technologies has fostered smart segmentators, the successive and simultaneous garnering global and local features still remains challenging, which is essential for an exact and efficient imageological assay. To this end, a segmentation solution dubbed the mixed parallel shunted transformer (MPSTrans) is developed here, highlighting 3D-MPST blocks in a U-form framework.
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