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Multithermal fluid (MTF) component ratios and injection parameters are critical inputs in offshore heavy oil development, such as injection adjustment and monitoring, productivity prediction, and generator combustion process optimization. We implement simultaneous in situ diagnostics of two emblematic injection parameters, the gas-water ratio (GWR) and noncondensable gases proportion (NCGP), in a pilot-scale environment. A system-level integration of a novel laser absorption spectroscopy multigas sensor system based on integrating stray radiation suppression and a circular cell-enhanced strategy is proposed. A structurally optimized extinction thread in front of a photodetector is designed to reduce the absorption signal distortion under the influence of high-temperature radiation. Meanwhile, we break the limitation of the internal dimensions of the injection tube on the long-path absorption of gas molecules and improve the absorbance signal SNR by 3.42-fold. The present work performed experimental tests using diesel as the primary fuel in a laboratory-scale MTF generation system. The results show that the measurement uncertainties for HO/CO concentrations are maintained at ±6.34% and ±6.87%, respectively. The proportion of CO in noncondensable gas is comparable to field data, but the GWR of the simulation system at different injection temperatures is much higher than that of the field injection parameters. The measurement system demonstrates remarkable stability and rapid response, marking a significant milestone as the first reported instance of in situ diagnostics of MTF injection parameters conducted in a laboratory bench test.
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http://dx.doi.org/10.1021/acs.analchem.4c05883 | DOI Listing |
Neurochem Res
September 2025
Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Parkinson's disease (PD) is characterized by impairments in motor control following the degeneration of dopamine-producing neurons located in the substantia nigra pars compacta. Environmental pesticides such as Paraquat (PQ) and Maneb (MB) contribute to the onset of PD by inducing oxidative stress (OS). This study evaluated the therapeutic efficacy of moderate physical activity (PA) on both motor and non-motor symptoms in a Wistar rat model of Paraquat and Maneb (PQ/MB) induced PD.
View Article and Find Full Text PDFPsychopharmacology (Berl)
September 2025
Instituto de Biología Celular y Neurociencias "Prof. De Robertis" (IBCN), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina.
Rationale: Autism spectrum disorders (ASD) are a group of neurodevelopmental and multifactorial conditions with cognitive manifestations. The valproic acid (VPA) rat model is a well-validated model that successfully reproduces the behavioral and neuroanatomical alterations of ASD. Previous studies found atypical brain connectivity and metabolic patterns in VPA animals: local glucose hypermetabolism in the prefrontal cortex, with no metabolic changes in the hippocampus.
View Article and Find Full Text PDFSmall
September 2025
Physical Chemistry, TU Dresden, Zellescher Weg 19, 01069, Dresden, Germany.
III-V semiconductor nanocrystals (NCs) have emerged as a benign alternative to II-VI and IV-VI NCs, which are restricted due to the toxicity of the comprising elements. While InP NCs advanced significantly, the development of infrared-emitting InAs NCs has been relatively slow-paced. This is due to the synthetic challenges arising from the highly covalent bonding in InAs and the limited range of available arsenic sources.
View Article and Find Full Text PDFVet World
July 2025
Department of Large Animal and Wildlife Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom, Thailand.
Background And Aim: Echocardiographic assessment in equines is typically performed on standing animals; however, no studies have evaluated left ventricular function in anesthetized mules using high-dose xylazine. Given the unique pharmacokinetics in mules and their higher anesthetic requirements, this study aimed to assess the effects of acepromazine-xylazine-diazepam-ketamine anesthesia, using the upper limit xylazine dose (1.6 mg/kg), on the left ventricular size and function in mules.
View Article and Find Full Text PDFDrug Deliv
December 2025
School of Pharmaceutical Sciences, Capital Medical University, Beijing, China.
Obesity is a global health crisis strongly linked to increased risk of type 2 diabetes, cardiovascular diseases, and other metabolic disorders. Glucagon-like peptide-1 (GLP-1) has emerged as an effective macromolecular therapeutic agent for weight management. This study addressed obesity management from three distinct perspectives: enhancing drug dispersion and bioavailability through a novel drug delivery device, extending drug half-life by developing sustained-release formulations, and sustaining the weight loss through implementation of structured dietary protocols.
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