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http://dx.doi.org/10.1212/WNL.0000000000213355 | DOI Listing |
Horm Metab Res
September 2025
Department of Obstetrics, Fujian Maternity and Child Health Hospital, Fuzhou, China.
The non-insulin-based metabolic score for insulin resistance (METS-IR) is a recently developed index aimed at being a practical and efficient alternative biomarker of insulin resistance (IR). This study aimed to investigate the association between METS-IR in euthyroid women in the first trimester of pregnancy and pregnancy outcomes. A total of 1810 participants who gave birth at Fujian Maternity and Child Health Hospital from November 2018 to November 2019 were included in this study.
View Article and Find Full Text PDFHealth Sci Rep
September 2025
Department of Dermatology the Union Hospital, Fujian Medical University Fuzhou People's Republic of China.
Background And Aims: Several observational studies have reported inconsistent associations between dyslipidaemia, stains use and atopic dermatitis (AD). Nevertheless, the available data on the effects of -C-lowering as well as TG-lowering drugs remain inconclusive and limited. The aim of this study was to evaluate the causal association of lipid traits and long-term use of lipid-lowering drugs on AD risk.
View Article and Find Full Text PDFCNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFJ Ethn Subst Abuse
September 2025
Başakşehir Çam and Sakura Hospital, Istanbul, Turkey.
This study was conducted in a descriptive and cross-sectional design to determine the physical health status of individuals with substance use disorders receiving inpatient treatment at an addiction treatment center. Data were collected between April 2023 and April 2024 at the Adult Detoxification Center of a psychiatric hospital in Istanbul, Türkiye. The sample consisted of a total of 261 individuals with substance use disorders (218 males and 43 females) who met the inclusion criteria.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Geriatrics, Lianyungang Hospital Affiliated to Jiangsu University, Lianyungang, China.
Cerebral small-vessel disease (CSVD) is an important risk factor for cognitive impairment, which is a pressing health issue for the aging population worldwide. The complex relationship between vascular factors, such as blood pressure variability (BPV) and arteriosclerosis index (AI), and cognitive dysfunction in patients with CSVD is a hot research topic, and research in this area will help prevent and treat cognitive dysfunction in CSVD. This study aims to investigate the effects of diastolic BPV (DBPV) and AI on cognitive function in patients with CSVD.
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