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Article Abstract
Background: Heart failure (HF) patients admitted to the intensive care unit (ICU) often face high short-term mortality rates. This study aims to investigate the relationship between lactate dehydrogenase (LDH) levels and all-cause mortality in critically ill patients with HF.
Methods: Data from the MIMIC-IV database were extracted for subjects eligible for HF diagnosis. We utilized the restricted cubic spline (RCS) method, Kaplan-Meier (K-M) survival curves, and Cox regression analysis to assess the association between lactate dehydrogenase (LDH) levels and all-cause mortality in HF patients. Overlap weighting (OW) and subgroup analysis were employed to enhance the robustness and reliability of the study.
Results: A total of 3,065 subjects were enrolled in this study. RCS analysis revealed a nonlinear relationship between LDH levels and the risk of all-cause mortality in critically ill patients with HF, with a hazard ratio (HR) > 1 when LDH exceeded 315 U/L. The K-M survival curve indicated lower survival rates and shorter survival times in subjects with LDH ≥ 315 U/L. Elevated LDH levels were independently associated with increased in-hospital and 1-year mortality rates, with adjusted HR of 1.39 (95% CI: 1.16, 1.67) and 1.29 (95% CI: 1.14, 1.45), respectively. The results remained consistently robust in the OW analyses.
Conclusions: Elevated LDH levels were significantly associated with an increased risk of all-cause mortality in ICU-admitted HF patients. Further randomized trials are needed to confirm this association.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776202 | PMC |
| http://dx.doi.org/10.1186/s12872-025-04513-1 | DOI Listing |
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