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http://dx.doi.org/10.1007/s00270-025-03967-2 | DOI Listing |
Indian J Nucl Med
August 2025
Department of Nuclear Medicine, Jawaharlal Institute of Post-Graduate Medical Education and Research, Puducherry, India.
Objectives: Bone scintigraphy is a sensitive imaging method to evaluate patients with suspected osteonecrosis. We assessed the diagnostic performance of combined bone single-photon emission computed tomography/computed tomography (SPECT/CT) (CBS) in patients with known rheumatic disease or other connective tissue disorders and clinical suspicion of osteonecrosis compared to magnetic resonance imaging (MRI).
Methods: This prospective diagnostic accuracy study included 70 patients with clinical suspicion of osteonecrosis in any bone who underwent a planar triple-phase bone scan along with a regional SPECT/CT (CBS) and regional MRI.
Microsurgery
September 2025
Department of Otorhinolaryngology - Head and Neck Surgery, Cantonal Hospital Lucerne, Lucerne, Switzerland.
Objective: Reconstruction after partial laryngectomy poses challenges in preserving voice, swallowing, and airway patency. Tailored laryngeal free-flap reconstructions using multiple chimeric perforator flaps aim to maximize functional preservation of the larynx and facilitate swallowing rehabilitation by enhancing larynx mobility.
Methods: Various compartmental laryngeal reconstructions using chimeric free flaps were performed on seven male patients (aged 40-82) with laryngeal malignancies following open partial laryngectomy.
Phys Chem Chem Phys
August 2025
Department of Chemistry, Anhui University, Hefei, Anhui 230601, P. R. China.
Pyramidane (C(CH)) and its derivatives have garnered considerable interest in organic and synthetic chemistry due to their distinctive pyramidal geometry. Nevertheless, the non-classical bonding pattern between the pyramidal apex and base remains insufficiently elucidated. This work firstly developed a two-dimensional (2D) superatom-atom super bonding framework, providing new insights into the bonding nature of C(CH).
View Article and Find Full Text PDFAcc Chem Res
August 2025
State Key Laboratory of Coordination Chemistry, Institute of Green Chemistry and Engineering, School of Chemistry and Chemical Engineering, Nanjing University, Suzhou, Jiangsu 215163, P. R. China.
ConspectusThe booming progress of organoboron chemistry has unleashed a profound revolution in the field of synthetic chemistry. Among emerging organoboron reagents, -diborylalkanes stand out as uniquely versatile platforms that unlock unconventional reaction pathways through activation of their dual boryl groups. The empty p orbitals of adjacent the boryl groups not only allow generation of α-boryl carbanionic intermediates but also enable precise selectivity controls, allowing chemists to navigate a previously inaccessible chemical space.
View Article and Find Full Text PDFInt J Chron Obstruct Pulmon Dis
May 2025
Respiratory Medicine, Paris Cité University, Paris, France.
Background: Chronic obstructive pulmonary disease (COPD) is a prevalent condition characterized by persistent airflow obstruction and respiratory symptoms. Single-Inhaler Triple Therapy (SITT) has been shown to improve patient adherence, reduce exacerbations, and lower healthcare resource utilization in patients who are not controlled despite being on dual therapy or Multiple-Inhaler Triple Therapy (MITT). Despite evidence supporting SITT, payer-driven access rules across Europe sometimes limit its use in primary care, creating barriers to optimal COPD management.
View Article and Find Full Text PDF