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Article Abstract
Four previously undescribed cyclic peptides, reniochpeptins A-D (1-4), were isolated from the marine sponge Reniochalina sp. Their structures were elucidated through comprehensive spectroscopic analyses and a modified advanced Marfey's method. This method utilized ultra-high-performance liquid chromatography coupled with tandem multiple reaction monitoring mass spectrometry, employing a CORTECS T column to achieve simultaneous separation of derivatized -Leu, -Ile, -allo-Ile, -Leu, -Ile, and -allo-Ile within 25 min in a single analytical run. Reniochpeptin A displayed moderate inhibitory activity against NCI-H460 cells, with an IC value of 4.7 μM, by inducing cell cycle arrest at the G2/M phase and promoting apoptosis.
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| http://dx.doi.org/10.1016/j.phytochem.2025.114412 | DOI Listing |
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