Publications by authors named "Xin-Li Lin"
Four previously undescribed cyclic peptides, reniochpeptins A-D (1-4), were isolated from the marine sponge Reniochalina sp. Their structures were elucidated through comprehensive spectroscopic analyses and a modified advanced Marfey's method. This method utilized ultra-high-performance liquid chromatography coupled with tandem multiple reaction monitoring mass spectrometry, employing a CORTECS T column to achieve simultaneous separation of derivatized -Leu, -Ile, -allo-Ile, -Leu, -Ile, and -allo-Ile within 25 min in a single analytical run.
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- Scientists discovered five new cycloheptapeptides, named phakefusins A-E, from the marine sponge Phakellia fusca using a probe-based molecular networking approach.
- Two of these compounds feature unique nonproteinogenic amino acids, while others have rare structural components such as methionine sulfoxide and glutamic acid ethyl ester.
- The compounds were tested for their biological activities, with compound 1 showing moderate antitumor effects and compounds 2-5 demonstrating antioxidant potential by enhancing certain protective enzyme levels.
Cyanogripeptides A-C (-), three new cyclolipopeptides with unusual β-methyl-leucine residues, were identified from an LHW52806 using an LC-MS-guided strategy. The structures of compounds - were elucidated by 1D/2D NMR, HR-MS/MS, and the advanced Marfey's method. The absolute configuration of the β-methyl-leucine residue was determined by a combination of stereoselective biosynthesis of (2,3)-β-methyl-leucine, racemization to its epimer (2,3)-β-methyl-leucine, and the advanced Marfey's method.
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