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Background: We aimed to investigate the outcome of patients after RDN at different time points.
Methods: We studied the outcomes of 77 living robotic living donor nephrectomies (RDN). Donors were separated into three groups: learning curve period (LCP), stabilisation period (SP), and teaching period (TP).
Results: There were significant differences in blood loss and hospitalisation times between the three groups. Operative time was significantly shorter in the LCP group compared with the SP and TP groups (282 ± 51.6 min vs. 308 ± 38.7 min vs. 314 ± 28.7, p = 0.02). However, warm ischaemia time was shorter in the TP group compared with the LCP and SP groups (5.0 ± 3.6 min vs. 3.4 ± 3.2 min vs. 1.5 ± 1.3 min, p < 0.01). Complication rates were higher in the LCP group compared with the SP and TP groups (p = 0.04).
Conclusion: This study demonstrated that RDN outcomes improve after the learning period.
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http://dx.doi.org/10.1002/rcs.70041 | DOI Listing |
Front Oncol
August 2025
Department of Radiology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.
Objectives: Lymph node metastasis (LNM) is an important factor affecting the stage and prognosis of patients with lung adenocarcinoma. The purpose of this study is to explore the predictive value of the stacking ensemble learning model based on F-FDG PET/CT radiomic features and clinical risk factors for LNM in lung adenocarcinoma, and elucidate the biological basis of predictive features through pathological analysis.
Methods: Ninety patients diagnosed with lung adenocarcinoma who underwent PET/CT were retrospectively analyzed and randomly divided into the training and testing sets in a 7:3 ratio.
Front Oncol
August 2025
Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Purpose: Identifying radiomics features that help predict whether glioblastoma patients are prone to developing epilepsy may contribute to an improvement of preventive treatment and a better understanding of the underlying pathophysiology.
Materials And Methods: In this retrospective study, 3-T MRI data of 451 pretreatment glioblastoma patients (mean age: 61.2 ± 11.
J Inflamm Res
September 2025
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Introduction: While nucleus pulposus cell (NPC) degeneration is a primary driver of intervertebral disc degeneration (IVDD), the cellular heterogeneity and molecular interactions underlying NPC degeneration remain poorly characterized. Previous studies have shown that EGFR signaling plays a significant role in NPC differentiation and collagen matrix production. Consequently, this study aims to identify the critical downstream regulatory molecule of EGFR in the process of NPC degeneration.
View Article and Find Full Text PDFBiochem Biophys Rep
June 2025
Department of Public Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Background: Synaptic dysfunction and synapse loss occur in Alzheimer's disease (AD). The current study aimed to identify synaptic-related genes with diagnostic potential for AD.
Methods: Differentially expressed genes (DEGs) were overlapped with phenotype-associated module selected through weighted gene co-expression network analysis (WGCNA), and synaptic-related genes.
Front Endocrinol (Lausanne)
September 2025
Department of Orthopedics I, Second Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China.
Background: Emerging evidence indicates that lactase-mediated histone lactylation can activate osteogenic gene expression and promote bone formation. However, the role of lactylation-related genes (LRGs) in osteoporosis (OP) remains unclear. This study aims to clarify the key roles of LRGs and the molecular mechanisms of related biomarkers in OP.
View Article and Find Full Text PDF