Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Non-invasive brain stimulation is promising for treating many neuropsychiatric and neurological conditions. It could be optimized by understanding its intracranial responses in different brain regions. We implanted multi-site intracranial electrodes and systematically assessed the acute responses in these regions to transcranial alternating current stimulation (tACS) at different frequencies. We observed robust neural oscillation changes in the hippocampus and amygdala in response to non-invasive tACS procedures, and these effects were frequency-specific and state-dependent. Notably, the hippocampus responded most strongly and stably to 10 Hz stimulation, with pronounced changes across a wide frequency range, suggesting the potential of 10 Hz oscillatory stimulation to modulate a broad range of neural activity related to cognitive functions. Future work with increased sample sizes is required to determine the clinical implications of these findings for therapeutic efficiency.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41380-025-02892-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Personalized Closed-Loop Brain Stimulation Protocol for Difficulty Falling Asleep.
IEEE Trans Neural Syst Rehabil Eng
June 2025
Insomnia, a common mental health issue, is characterized by brain hyperarousal and difficulties in transitioning between sleep stages. Pharmacological interventions often come with adverse effects and variable efficacy, while non-invasive brain stimulation holds potential but lacks in providing tailored, dynamic, and precisely targeted solutions. A novel online closed-loop individualized frequency transcranial alternating current stimulation protocol (IF-tACS) was developed to dynamically adjust the stimulation sites and parameters in sync with sleep states.
View Article and Find Full Text PDFFrequency- and state-dependent dynamics of EEG microstates during propofol anesthesia.
Neuroimage
April 2025
School of Life Science and Technology, Xidian University, Xi'an, PR China. Electronic address:
Electroencephalography microstate analysis has emerged as a powerful tool for investigating brain dynamics during anesthesia-induced unconsciousness. However, existing studies typically analyze EEG signals across broad frequency bands, leaving the frequency-specific temporal characteristics of microstates poorly understood. In this study, we investigated frequency-specific EEG microstate features in the delta (0.
View Article and Find Full Text PDFFrequency-specific and state-dependent neural responses to brain stimulation.
Mol Psychiatry
July 2025
Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine and School of Psychology, Shanghai, China.
Article Synopsis
- Non-invasive brain stimulation shows potential for treating various neuropsychiatric and neurological conditions, with optimization possible through understanding its effects in different brain regions.
- Researchers used implanted electrodes to analyze acute responses to transcranial alternating current stimulation (tACS) at various frequencies, discovering significant neural changes, particularly in the hippocampus and amygdala.
- The study found that 10 Hz stimulation in the hippocampus produced the strongest and most consistent effects, suggesting that this frequency could enhance cognitive functions, but further research with larger samples is needed to explore its clinical applications.
Different vulnerability of fast and slow cortical oscillations to suppressive effect of spreading depolarization: state-dependent features potentially relevant to pathogenesis of migraine aura.
J Headache Pain
January 2024
Department of Molecular Neurobiology, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova Street 5A, 117485, Moscow, Russia.
Background: Spreading depolarization (SD), underlying mechanism of migraine aura and potential activator of pain pathways, is known to elicit transient local silencing cortical activity. Sweeping across the cortex, the electrocorticographic depression is supposed to underlie spreading negative symptoms of migraine aura. Main information about the suppressive effect of SD on cortical oscillations was obtained in anesthetized animals while ictal recordings in conscious patients failed to detect EEG depression during migraine aura.
View Article and Find Full Text PDFInterregional phase-amplitude coupling between theta rhythm in the nucleus tractus solitarius and high-frequency oscillations in the hippocampus during REM sleep in rats.
Sleep
April 2023
Krembil Research Institute, University of Toronto, Toronto, ON, Canada.
Cross-frequency coupling (CFC) between theta and high-frequency oscillations (HFOs) is predominant during active wakefulness, REM sleep and behavioral and learning tasks in rodent hippocampus. Evidence suggests that these state-dependent CFCs are linked to spatial navigation and memory consolidation processes. CFC studies currently include only the cortical and subcortical structures.
View Article and Find Full Text PDF