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Article Abstract
Background: Informational integration and differentiation of the cortex can be tested by methods such as the perturbational complexity index (PCI) combined with TMS-induced activity perturbation. The PCI is obtained by stimulating the cortex with TMS and measuring the resulting spatiotemporal cortical responses with high-density EEG.
Methods: We have compared PCI between 26 patients with schizophrenia (15 males), 15 of them First Episode (FE) (7 males), and 22 healthy controls (12 males).
Results: Values of PCI were significantly lower in patients with schizophrenia, as well as in FE considered alone. There was no significant relation between anomalous self-experiences or symptoms and PCI values in the patients: PCI values were unrelated to treatment doses or illness duration.
Conclusions: Our data suggest that spatiotemporal cortical responses to TMS pulses are reduced in patients regarding variability or spatial extension, which could imply a lower capacity for sustaining informational complexity.
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| http://dx.doi.org/10.1016/j.pnpbp.2025.111254 | DOI Listing |
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