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Parenting programs have proven effective in reducing disruptive child behavior. However, not all families benefit equally, and, to date, we have little insight into who benefits more or less and why. One possible solution is to explore how different potential moderators cluster together in individual families and whether such family profiles predict who benefits more or less from these programs. This study explores (a) how family, child, and parenting risk factors for disruptive behavior cluster together in families enrolled in the popular and evidence-based Incredible Years Parenting Program using latent profile analyses; (b) how family profiles relate to covariate family characteristics; and (c) whether profiles predict program engagement (i.e., number of sessions attended by caregivers) and effectiveness of (i.e., pre-post changes in disruptive behavior). Individual participant data from six studies across four countries (Norway, the Netherlands, England, Portugal) were used, including a total sample of 772 families with children aged 2.5-9 years ( = 5.14; = 1.10; 58.0% boys). Families could be profiled into a low- and high-risk profile, which differed on most child and family (but not parenting) risk factors as well as on covariate family characteristics, such as severity of disruptive behavior. Profile membership predicted engagement in, but not effectiveness of, the program. These findings provide useful insights into the heterogeneity in families participating in parenting programs, although there is a need for further research on how such differences may relate to differences in program effectiveness. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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http://dx.doi.org/10.1037/fam0001275 | DOI Listing |
Genome Biol
September 2025
Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Biology, Plön, Germany.
Background: Most RNA-seq datasets harbor genes with extreme expression levels in some samples. Such extreme outliers are usually treated as technical errors and are removed from the data before further statistical analysis. Here we focus on the patterns of such outlier gene expression to investigate whether they provide insights into the underlying biology.
View Article and Find Full Text PDFDiabetes Res Clin Pract
September 2025
University of Miami, Pediatrics, 1601 NW 12(th) Ave, Miami, FL 33136, the United States of America. Electronic address:
Aims: Examine the mediating roles of family conflict (FC) and diabetes self-management behaviors (SMB) in the relationship between behavioral self-control (BSC) and glycemic levels in adolescents with type 1 diabetes (T1D). We predicted that BSC would improve glycemic levels directly and indirectly by decreasing FC and increasing SMB, both cross-sectionally and longitudinally.
Methods: 172 adolescents (M age = 16 years) with T1D were followed for three years at three medical centers.
Gene
September 2025
Department of Otorhinolaryngology Head and Neck Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China. Electronic address:
Background: Nasopharyngeal carcinoma (NPC) pathogenesis is multi-factorial, involving synergistic interactions among genetic susceptibility, Epstein-Barr virus (EBV) infection, and environmental exposures. Notably, specific multi-generational families exhibit NPC incidence substantially exceeding both sporadic cases and general genetic susceptibility cohorts, demonstrating Mendelian inheritance patterns. This supports the hypothesis that high penetrance pathogenic variants dominate disease initiation and progression in familial NPC.
View Article and Find Full Text PDFJ Am Acad Orthop Surg
September 2025
From the University of Texas Health Science Center at Houston, Houston, Texas (Osadebey), University of South Carolina School of Medicine, Greenville, South Carolina, Sports Medicine and Shoulder Reconstruction at Prisma Health (Pill), Department of Orthopedic Surgery at Stanford University, Redwood
Management of acromioclavicular separations remains controversial. A variety of surgical techniques have been described, but no clear consensus has formed regarding optimal treatment. As these techniques have evolved, so have the complication profiles.
View Article and Find Full Text PDFAm J Audiol
September 2025
Department of Special Education and Communication Disorders, University of Nebraska-Lincoln.
Purpose: This study investigated the effects of age-related hearing decline on functional networks using resting-state functional magnetic resonance imaging (rs-fMRI). The main objective of the present study was to examine resting-state functional connectivity (RSFC) and graph theory-based network efficiency metrics in 49 adults categorized by age and hearing thresholds to identify the neural mechanisms of age-related hearing decline.
Method: Forty-nine adults with self-reported normal hearing underwent pure-tone audiometry and rs-fMRI.