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http://dx.doi.org/10.1111/apt.18463 | DOI Listing |
Front Pharmacol
August 2025
Master's Program in Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Introduction: Multi-organ toxicity, including nephrotoxicity, is a major drawback to the use of doxorubicin in chemotherapy. This study investigated the protective effect and possible mechanism of action of a standardized ethanolic extract of (Burm.f.
View Article and Find Full Text PDFFront Cell Infect Microbiol
August 2025
Friedrich Loeffler - Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Background: Intracellular invasion and persistence of can lead to chronic infection and is an effective strategy for the pathogen to evade the host immune response and antibiotic therapy. Selective ubiquitination of bacterial surfaces via E3 ubiquitin ligases is a mechanism by which host cells combat intracellular bacteria and target them for autophagosomal degradation. However, knowledge of the E3 ligases involved in intracellular recognition of is still very limited.
View Article and Find Full Text PDFACS Med Chem Lett
August 2025
Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
This patent describes novel leucine-rich repeat kinase 2 (LRRK2) inhibitors featuring a 2,4,12,13-tetrahydro-11-5,7-(azenometheno)-dipyrazolo-[3,4-:5',1'-]-[1]-oxa-[4,6,8]-triazacycloundecine scaffold. These LRRK2 inhibitors exhibit therapeutic potential for the treatment of Parkinson's disease.
View Article and Find Full Text PDFFront Plant Sci
July 2025
State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Nanning, China.
Introduction: The Anacardiaceae family, encompassing economically and ecologically significant genera such as , , and , exhibits substantial genomic diversity and adaptive complexity. However, comparative genomic analysis and evolutionary insights into defense-related mechanisms within this family remain underexplored.
Methods And Results: This study employed a comprehensive phylogenomic, synteny, and gene family analysis across six species and three additional Anacardiaceae plants (, , and ).
Parkinsonism Relat Disord
September 2025
Department of Neurology, University of Rochester Medical Center, NY, USA; Center for Health + Technology, University of Rochester Medical Center, NY, USA. Electronic address:
Background: Interest in Parkinson's disease (PD) prevention trials is growing, and genetically at-risk individuals may be ideal candidates. LRRK2 G2019S is the most common autosomal dominant genetic cause of PD and exhibits incomplete penetrance.
Objective: In a remote, prospective cohort study of LRRK2 G2019S carriers without PD, we examined change over time to better understand the natural history of LRRK2 PD.