Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Anamorelin, a highly selective ghrelin receptor agonist, enhances appetite and increases lean body mass in patients with cancer cachexia. However, the predictors of its therapeutic effectiveness are uncertain. This study aimed to investigate the association between the Glasgow prognostic score (GPS), used for classifying the severity of cancer cachexia, the therapeutic effectiveness of anamorelin, and the feasibility of early treatment based on cancer types. A retrospective analysis included patients with gastric, pancreatic, colorectal, and non-small-cell lung cancer treated with anamorelin between May 2021 and July 2022. The endpoints were the response rate for increased appetite within 3 weeks of treatment initiation and the time to treatment failure (TTF) due to therapeutic failure of anamorelin. Multivariate logistic regression model and Fine and Gray's model were used for analysis. Of the 137 patients in this analysis, 51% of patients had a GPS of 0 or 1, and 49% of those had a GPS of 2. Patients with a GPS of 2 showed a lower response for increased appetite than those with a GPS of 0 or 1 (adjusted odds ratio 0.29 [95% CI 0.12-0.72], P = 0.007). Additionally, TTF was shorter in patients with a GPS of 2 with a GPS of 0 or 1 (adjusted subdistribution hazard ratio 2.22 [95% CI 1.22-4.03], P = 0.009). Anamorelin could be more effective in improving appetite and prolonging the duration of treatment effect in patients with a GPS of 0 or 1 than those with a GPS of 2.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10637-024-01503-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Determinants of sustainable adoption in primary care of a clinical decision support system for antimicrobial prescribing: A qualitative study.
Infect Dis Now
September 2025
Université Paris Cité, INSERM, IAME, F-75018 Paris, France; Infectious and Tropical Diseases Department, Bichat-Claude Bernard Hospital, AP-HP, F-75018 Paris, France.
Objective: The objective of the study was to analyse the determinants for sustainable adoption by General Practitioners (GPs) of Antibioclic, a Clinical Decision Support System (CDSS) for antimicrobial prescribing, and the results of and limitations to its use in clinical practice.
Materials And Methods: Individual interviews with GPs and a focus group were carried out concerning their use of Antibioclic, a CDSS for antimicrobial prescribing in primary care. Antibioclic is a publicly funded, freely available CDSS targeting 48 common infectious diseases.
Creatinine clearance, reduced kidney function, and optimizing prescribing safety through practice feedback: a mixed methods study.
Fam Pract
August 2025
Division of Primary Care, Palliative Care and Public Health, Leeds Institute of Health Sciences, University of Leeds, Leeds LS2 9LN, United Kingdom.
Background: Kidney function declines with age, increasing risk of harm from raised blood levels of many medicines. Prescribing is often inappropriate for older people with reduced creatinine clearance (CrCl).
Objective: To examine the feasibility and acceptability of providing performance feedback to increase CrCl calculation and coding and reduce potentially inappropriate prescribing.
Perceptions of hypnotherapy for children with functional abdominal pain: a qualitative study.
Fam Pract
August 2025
Department of Primary and Long-Term Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Background: Hypnotherapy is an effective treatment for children with functional abdominal pain in secondary care. However, children usually present first to general practitioners (GPs) in Dutch primary care, and it is unknown how children, parents, and GPs perceive hypnotherapy in this setting.
Objective: To explore the perceptions of children, parents, and GPs about hypnotherapy in primary care for children with functional abdominal pain.
Postgraduate medically related qualifications of early career general practitioners.
Aust J Gen Pract
September 2025
MBBS (Hons), PhD, FRACGP, Conjoint Professor, School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW; Senior Manager, General Practice Training Research Team, The Royal Australian College of General Practitioners, Melbourne, Vic.
Background And Objectives: General practitioners' (GPs) specialised qualifications and upskilling in medical roles strengthen healthcare systems and improve patient outcomes. This study aimed to describe additional qualifications attained, or being undertaken, by early career GPs and establish associations of obtaining/undertaking postgraduate and post-Fellowship qualifications.
Method: This was a questionnaire-based, cross-sectional study of early career college-Fellowed GPs in NSW/ACT, Tasmania and Eastern Victoria (New alumni Experiences of Training and independent Unsupervised Practice [NEXT-UP] study).
A qualitative analysis of a nationally representative survey of the state of chronic non-cancer pain management in Australia.
Aust J Gen Pract
September 2025
PhD, Associate Professor, School of Psychology, The University of Queensland, Brisbane, Qld; Affiliate Associate Professor, Department of Rehabilitation Medicine, The University of Washington, Seattle, WA, USA.
Background And Objectives: Although general practitioners (GPs) are the first-line treatment providers for chronic non-cancer pain (CNCP) in Australia, the experience of patients in this context is not well documented. This study explored patients' experiences with GPs managing their CNCP.
Method: Qualitative responses to two open-ended questions about GP care from adult respondents (n=200) to Chronic Pain Australia's 2021 National Pain Survey were thematically analysed.