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Alkaline salts have more severe adverse effects on plant growth and development than neutral salts do. However, the adaptive mechanisms of plants to alkaline salt stress remain poorly understood, especially at the molecular level. The Songnen Plain in northeast China is composed of typical 'soda' saline-alkali soil, with NaHCO and NaCO as the predominant alkaline salts (pH ≥ 9.2). Leymus chinensis can grow on this saline-alkali land, showing strong adaptability. We investigated the role of succinic acid and genes regulating its synthesis in the response to alkaline salt stress in L. chinensis roots. Compared to the neutral salt (NaCl) and high pH treatments, the alkaline salt (NaHCO and NaCO) treatment specifically caused changes in 11 organic acids, of which the increase in succinic acid was the greatest. The exogenous addition of succinic acid alleviates the damage of alkaline salt to L. chinensis roots. Further, two genes encoding succinyl-coenzyme A ligase (SUCLA) subunits that regulate succinic acid synthesis, LcSUCLAα and LcSUCLAβ, were identified; these genes interact and were localized within mitochondria. Overexpression of LcSUCLAα and LcSUCLAβ caused an increase in succinic acid and enhanced tolerance of NaHCO in transgenic rice seedlings. These results suggest that LcSUCLAα and LcSUCLAβ may be involved in the response to alkaline salt stress through the regulation of succinic acid synthesis.
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http://dx.doi.org/10.1016/j.plaphy.2025.109485 | DOI Listing |
J Pediatr Urol
August 2025
Gaziantep University Medical Faculty, Department of Urology, Gaziantep, Turkey. Electronic address:
Objective: The most common chronic complication of vesicoureteral reflux (VUR) is the presence of renal scarring and dimercapto succinic acid (DMSA) renal scan is utilized for its detection. In this study, we have aimed to assess whether shear wave speed (SWS) differs between normal and refluxing kidneys.
Materials And Method: Fifty pediatric VUR patients and 21 healthy children with available DMSA obtained within the previous year were included in the study.
Carbohydr Polym
November 2025
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China. Electronic address:
The inefficiency of traditional pesticides leads to significant resource waste, severe environmental pollution, and potential threats to human health. Pesticide microcapsules present a promising strategy for developing environmentally friendly, safe, and sustained-release formulations. In this study, we produced degradable starch nanocrystals (SNCs) via acid hydrolysis and employed octenyl succinic anhydride-modified SNCs (O-SNCs) to fabricate pesticide microcapsules.
View Article and Find Full Text PDFInt J Pharm
September 2025
Chemical and Biochemical Engineering, Western University, London, Ontario N6A 5B9, Canada. Electronic address:
Salts and cocrystals are vital multicomponent entities for tuning pharmaceuticals' solid-state properties, yet their experimental screening is labor-intensive and often inefficient. We introduce a DualNet Ensemble algorithm, a multi-class classification model that integrates molecular graph embeddings with curated physicochemical descriptors to predict the formation of salts, cocrystals, or physical mixtures while estimating predictive uncertainty. The proposed DualNet was trained on 70 % of a curated dataset containing 22,298 experimentally validated entries.
View Article and Find Full Text PDFBiomaterials
September 2025
Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Hubei Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, 430074, China.
Bladder cancer remains a formidable challenge, especially for patients who fail to respond adequately to immune checkpoint inhibitors (ICIs). The suboptimal efficacy of current treatments underscores an urgent need for more effective immunomodulatory strategies. Here, we propose a ROS-responsive resiquimod (R848) prodrug (R-P) that improves drug delivery and reshapes the immunosuppressive tumor microenvironment.
View Article and Find Full Text PDFLangmuir
September 2025
Facultad de Ciencias Químicas, Departamento de Química Orgánica, Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina.
In this study, we demonstrate a novel, environmentally friendly approach to synthesizing gold (AuNPs) and silver (AgNPs) nanoparticles (NPs) using industrial lactic acid as a reducing agent and amphiphilic β-cyclodextrins modified with dodecenyl succinic anhydride (β-CDMod) as stabilizing ligands. The synthesized NPs, AuNPs@CDModDS1, AuNPs@CDModDS5, and AgNPs@CDModDS5, exhibit stable surface plasmon resonance band characteristics and remain colloidally stable in water for up to three weeks. Transmission electron microscopy revealed spherical NPs with varying sizes: AuNPs@CDModDS1 (6.
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