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Purpose: Uncovering the racial/ethnic health disparities that exist within cardiovascular medicine offers potential to mitigate treatment gaps that might affect outcomes. Socioeconomic status (SES) may be a more appropriate underlying factor to assess these disparities. We aimed to evaluate whether adherence, attendance, and outcomes in cardiac rehabilitation are associated with SES in a safety net hospital.
Methods: We analyzed 542 patients in a retrospective cohort study of the Cardiac Rehabilitation Program at Boston Medical Center from 2016 to 2019. Enrollees had a mean age of 59.4 years, 34% were female, 42% Black, and 12% Hispanic. The zip codes of each enrollee were used to obtain their area deprivation index (ADI). The ADI reflects income, education, employment, and housing quality within a given zip code. Associations between ADI and adherence and attendance rate were evaluated while controlling for covariates. Secondary outcomes included associations of ADI with change in exercise capacity, low density lipoprotein cholesterol, weight, quality of life, nutrition, and depression scores.
Results: We applied logistic regression to examine the association between adherence and ADI with adjustment on the covariates. The attendance rate was analyzed with negative binomial regression with percent of sessions attended as prescribed as a dependent variable and adjusted on the same covariates. The primary outcome revealed no association for ADI with adherence to cardiac rehabilitation (OR = 0.91: 95% CI, 0.74-1.12) or attendance rate (RR = 0.91: 95% CI, 0.80-1.04). Utilizing multiple linear regression, secondary outcomes improved among patients regardless of ADI.
Conclusions: We found equity in our cardiac rehabilitation program outcomes despite SES.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864041 | PMC |
http://dx.doi.org/10.1097/HCR.0000000000000927 | DOI Listing |
ESC Heart Fail
September 2025
Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
Heart failure (HF) is a multifactorial and pathophysiological complex syndrome, involving not only neurohormonal activation but also oxidative stress, chronic low-grade inflammation, and metabolic derangements. Central to the cellular defence against oxidative damage is nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that orchestrates antioxidant and cytoprotective responses. Preclinical in vitro and in vivo studies reveal that Nrf2 signalling is consistently impaired in HF, contributing to the progression of myocardial dysfunction.
View Article and Find Full Text PDFJ Am Geriatr Soc
September 2025
Frailty Research Center, Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
Background: Prehabilitation may help older adults recover after surgery, yet adherence has been variable. We assessed the feasibility of a multi-component prehabilitation program.
Methods: This single-arm trial was conducted at an academic medical center to test the feasibility of an individualized prehabilitation program before major surgery.
Gene
September 2025
Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China; Department of Neck and Thoracic Surgery, Yingde People's Hospital, Yingde, Guangdong, China. Electronic add
Background: Recurrent 10p15.3 microdeletion syndrome is a rare multisystem disorder characterized by abnormal facial features, global developmental delay (DD)/intellectual disability (ID), short stature, hand/foot malformation, and congenital heart defects (CHDs). However, the specific genetic defects that contribute to the cardiac phenotype remain unclear.
View Article and Find Full Text PDFJ Cardiol
September 2025
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan.
Background: Preoperative physical frailty is a significant predictor of adverse postoperative outcomes in older patients undergoing cardiac surgery. Inflammation plays a crucial role in the development of frailty and contributes to postoperative complications. This study investigated the effects of preoperative beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine supplementation on inflammatory markers, nutritional status, and renal function in older patients undergoing cardiac surgery.
View Article and Find Full Text PDFCan J Cardiol
September 2025
TotalCardiology Research Network, Calgary, AB; Department of Psychology, University of Regina, SK.
Despite its relevance to cardiovascular health, obesity is rarely targeted during cardiac rehabilitation (CR). The objective of this paper was to review evidence regarding whether measures to address excess body fat should be offered as a standard component of CR for patients with obesity. We organize the paper around three themes: 1) outcomes of obesity management, 2) the complexity of obesity management, and 3) patient attitudes, experiences, and preferences.
View Article and Find Full Text PDF