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http://dx.doi.org/10.1136/jitc-2024-011189 | DOI Listing |
Front Immunol
September 2025
Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Background: Tertiary lymphoid structures (TLSs) are linked to prognosis in esophageal squamous cell carcinoma (ESCC), but whether the distribution, abundance, and maturity of TLSs affect therapeutic efficacy and prognosis in ESCC treated with neoadjuvant chemoradiotherapy plus immunotherapy (NRCI) remains unclear. We explored TLS characteristics and correlated them with patient survival.
Methods: A total of 157 resectable ESCC patients treated with neoadjuvant therapy between September 2020 and May 2023 were divided into NRCI (n=49) and neoadjuvant chemoimmunotherapy (NCI, n=108) groups.
Curr Med Imaging
August 2025
Department of Medical Imaging Center, The First Affiliated Hospital of Medical College, Shihezi University, Medical Imaging Center, Shihezi, China.
Introduction: Accurate preoperative grading of adult-type diffuse gliomas is crucial for personalized treatment. Emerging evidence suggests tumor cell infiltration extends beyond peritumoral edema, but the predictive value of radiomics features in these regions remains underexplored.
Method: A retrospective analysis was conducted on 180 patients from the UCSF-PDGM dataset, split into training (70%) and validation (30%) cohorts.
Int J Surg Pathol
September 2025
Facultad de Medicina, Universidad del Norte, Asunción, Paraguay.
This study investigates the interplay between PD-L1, FOXP3+ regulatory T cells, and CD8+ cytotoxic T lymphocytes in penile squamous cell carcinoma (penile SCC), where understanding the tumor immune microenvironment is crucial. We analyzed 108 penile SCC specimens using tissue microarrays (528 spots). Immunohistochemistry was performed for PD-L1, FOXP3, and CD8.
View Article and Find Full Text PDFCancer Diagn Progn
September 2025
Medical School, Laboratory of Anatomy-Histology-Embryology, University of Ioannina, Ioannina, Greece.
Background/aim: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer accounting for 75-85% of cases. Despite its favorable prognosis, 30-50% of patients develop regional lymph node metastases. Lymphatic vessel density (LVD) is a potential predictor of tumor progression, metastasis, and patient survival in PTC.
View Article and Find Full Text PDFTechnol Cancer Res Treat
September 2025
Department of Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
BackgroundLymphovascular invasion (LVI) is a critical factor in breast cancer (BC) prognosis and treatment planning, yet preoperative non-invasive assessment remains challenging. This research proposes the design and validation of a comprehensive artificial intelligence (AI) system that combines intratumoral and peritumoral radiomic analysis, deep learning (DL)-derived features, and clinical risk indicators extracted from dynamic contrast-enhanced MRI (DCE-MRI), with the goal of predicting LVI status in patients with BC.MethodsThis multi-institutional retrospective study included 496 IBC patients (training cohort: n = 344; validation cohort: n = 152).
View Article and Find Full Text PDF