Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Two new phytoecdysteroids, (24)-20,26-dihydroxy-24(28)-dehydro-28-methyl-ecdysone (), (24)-22,25-epoxy-2,3,14,20-tetrahydroxyergosta-7,24(28)-dien-28-methyl-6-one (), together with eleven known compounds (-) were isolated from the whole plant of L. The chemical structures of the compounds were elucidated by 1D and 2D NMR and HR-ESI-MS and compared with data from the literature. The isolated compounds were evaluated for their inhibitory effects on NO, TNF-α and IL-6 production in LPS-induced RAW 264.7 cells. Among them, compounds , , , and showed anti-inflammatory effects against NO, TNF-, and IL-6 levels with IC values ranging from 30.44 ± 2.10 to 66.88 ± 2.32 μM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2024.2448726 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bidirectional effect of ecdysterone on thymocyte volume regulation and proliferation.
Steroids
September 2025
Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent 100174, Uzbekistan; Department of Biophysics, National University of Uzbekistan, Tashkent 100174, Uzbekistan. Electronic address:
The development and maturation of T cells requires an efficient cell volume regulation (CVR) system in which the volume-sensitive outwardly rectifying anion channel (VSOR/VRAC) plays a pivotal role. Ecdysterone (20-hydroxyecdysone, 20HE) is known to exert multiple effects in mammals, but the response of the thymus and thymocytes to this hormone remains virtually unexplored. In the present study, we observed a bidirectional effect of 20HE on the thymus and its cellular contents.
View Article and Find Full Text PDFTwo new phytoecdysteroids isolated from .
Nat Prod Res
January 2025
Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University College of Pharmacy, Yanji, P.R. China.
Two new phytoecdysteroids, (24)-20,26-dihydroxy-24(28)-dehydro-28-methyl-ecdysone (), (24)-22,25-epoxy-2,3,14,20-tetrahydroxyergosta-7,24(28)-dien-28-methyl-6-one (), together with eleven known compounds (-) were isolated from the whole plant of L. The chemical structures of the compounds were elucidated by 1D and 2D NMR and HR-ESI-MS and compared with data from the literature. The isolated compounds were evaluated for their inhibitory effects on NO, TNF-α and IL-6 production in LPS-induced RAW 264.
View Article and Find Full Text PDFPhytoecdysteroids: Quantification in Selected Plant Species and Evaluation of Some Effects on Gastric Smooth Muscles.
Molecules
October 2024
Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Phytoecdysteroids (PEs) are naturally occurring steroid compounds, that have recently gained significant attention, due to their diverse biological activities and high therapeutic potential. The aim of the present study was to quantify some PEs including 20-hydroxyecdysterone (20-HE), ponasterone A (PA), and turkesterone (TU) in selected plant foods and extract. Furthermore, the effects of 20-HE, TU, and extract, were investigated with in vitro methods using isolated smooth muscle tissues.
View Article and Find Full Text PDFPhytoecdysteroids from Dioscorea dumetorum (Kunth) Pax. and their antioxidant and antidiabetic activities.
Fitoterapia
September 2024
Institut für Chemie, University of Potsdam, Karl-Liebknecht-Strasse 24-25, D-14476 Potsdam-Golm, Germany.
Diabetes is a significant global health challenge, affecting circa 540 million adults worldwide. Dioscorea dumetorum, a Nigerian folkloric antidiabetic plant is severely understudied in terms of its bioactive phytochemical constituents. Antidiabetic guided isolation of the tubers and peels of D.
View Article and Find Full Text PDFIntegration of virtual screening of phytoecdysteroids as androgen receptor inhibitors by 3D-QSAR Model, CoMFA, molecular docking and ADMET analysis: An extensive and interactive machine learning.
J Steroid Biochem Mol Biol
March 2024
Micro-Biology Laboratory, Department of Chemistry, Government College Women University Faisalabad, 38000, Pakistan.
Ecdysteroids, a class of naturally isolated polyhydroxylated sterols, stands at a very good place in the pharmaceutical industry from their medicinal point of views like anti-inflammatory, neuroprotective, anti-microbial, anti-diabetic, antioxidant, and anti-tumor effects. Due to their excellent antioxidant and anti-microbial potential, ecdysteroids have extensive use in skin products, especially derma creams. To monitor the best anti-acne phytoecdysteroids, here made use of different computational approaches, by using the rapid, easy, cost-effective and high throughput method to screen and identify ecdysteroids as androgen receptor inhibitors.
View Article and Find Full Text PDF