Interleukin-1 Blockade in Myocardial Infarction and Its Efficacy in Patients With Complex Coronary Artery Disease: Another Brick in the Wall.

J Cardiovasc Pharmacol

School of Cardiovascular and Metabolic Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, London, United Kingdom ; and.

Published: March 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1097/FJC.0000000000001666DOI Listing

Publication Analysis

Top Keywords

interleukin-1 blockade
4
blockade myocardial
4
myocardial infarction
4
infarction efficacy
4
efficacy patients
4
patients complex
4
complex coronary
4
coronary artery
4
artery disease
4
disease brick
4

Similar Publications

Background: Familial Mediterranean fever (FMF) is the most frequent monogenic autoinflammatory disease in Germany. Genetic testing for Mediterranean FeVer (MEFV) variants is essential for diagnostic confirmation, although its impact on therapeutic decisions remains largely unclear.

Objective: Investigation of the correlation between MEFV variant type and disease course as well as the need for treatment escalation with Interleukin (IL)-1-Inhibitors.

View Article and Find Full Text PDF

Desmoplakin Cardiomyopathy Presenting With Recurrent Myopericarditis Responsive to Interleukin-1 Blockade.

JACC Case Rep

August 2025

Department of Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA. Electronic address:

Acute myopericarditis in patients with pathogenic desmoplakin (DSP) variants are associated with a high risk for heart failure and cardiac arrhythmias. We present the case of a 25-year-old woman who presented with recurrent myopericarditis with chest pain and elevated troponin I levels despite escalating prednisone therapy. Genetic testing revealed a pathogenic variant in DSP along with a pathogenic variant in KCNQ1 associated with long-QT syndrome and a NOD2 variant associated with an increased risk for Crohn disease.

View Article and Find Full Text PDF

Post-stroke cognitive impairment (PSCI) is a common and debilitating complication of stroke that significantly hinders rehabilitation. Electroacupuncture (EA), which integrates traditional acupuncture with electrical stimulation, has been widely applied in clinical practice and shown remarkable efficacy in treating PSCI. However, its underlying mechanisms remain largely unexplored.

View Article and Find Full Text PDF

Introduction: Syndrome of undifferentiated recurrent fever (SURF) refers to a group of recurrent fevers without a clear monogenic cause. Clinical spectrum, treatment response predictors and management strategies remain unclear.

Objective: This study aims to longitudinally analyse a homogeneously selected cohort of 101 SURF patients, to identify factors associated with colchicine resistance and to evaluate the efficacy of interleukin-1 (IL-1) inhibitors.

View Article and Find Full Text PDF

: Alcoholic hepatitis (AH) is a growing public health concern with its rising incidence and its contribution to nearly half of all cirrhosis-related deaths in the United States. In this systematic review, we aimed to comprehensively evaluate the current evidence and trials on the use of anti-interleukin-1 (anti-IL-1) drugs in patients with AH, assessing their efficacy and adverse events compared to routinely prescribed drugs like corticosteroids. : A comprehensive literature search was conducted across five databases to identify randomized controlled trials (RCTs) evaluating the role of anti-IL-1 agents like canakinumab and anakinra among patients diagnosed with AH.

View Article and Find Full Text PDF