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http://dx.doi.org/10.1097/FJC.0000000000001666 | DOI Listing |
Z Rheumatol
August 2025
Asklepios Kinderklinik, Sankt Augustin, Deutschland.
Background: Familial Mediterranean fever (FMF) is the most frequent monogenic autoinflammatory disease in Germany. Genetic testing for Mediterranean FeVer (MEFV) variants is essential for diagnostic confirmation, although its impact on therapeutic decisions remains largely unclear.
Objective: Investigation of the correlation between MEFV variant type and disease course as well as the need for treatment escalation with Interleukin (IL)-1-Inhibitors.
JACC Case Rep
August 2025
Department of Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA. Electronic address:
Acute myopericarditis in patients with pathogenic desmoplakin (DSP) variants are associated with a high risk for heart failure and cardiac arrhythmias. We present the case of a 25-year-old woman who presented with recurrent myopericarditis with chest pain and elevated troponin I levels despite escalating prednisone therapy. Genetic testing revealed a pathogenic variant in DSP along with a pathogenic variant in KCNQ1 associated with long-QT syndrome and a NOD2 variant associated with an increased risk for Crohn disease.
View Article and Find Full Text PDFNeurochem Res
August 2025
Rehabilitation Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Post-stroke cognitive impairment (PSCI) is a common and debilitating complication of stroke that significantly hinders rehabilitation. Electroacupuncture (EA), which integrates traditional acupuncture with electrical stimulation, has been widely applied in clinical practice and shown remarkable efficacy in treating PSCI. However, its underlying mechanisms remain largely unexplored.
View Article and Find Full Text PDFRMD Open
August 2025
Rheumatology and Autoinflammatory Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy
Introduction: Syndrome of undifferentiated recurrent fever (SURF) refers to a group of recurrent fevers without a clear monogenic cause. Clinical spectrum, treatment response predictors and management strategies remain unclear.
Objective: This study aims to longitudinally analyse a homogeneously selected cohort of 101 SURF patients, to identify factors associated with colchicine resistance and to evaluate the efficacy of interleukin-1 (IL-1) inhibitors.
Life (Basel)
July 2025
Department of Gastroenterology, Queen Elizabeth Hospital, Gateshead NE9 6SX, UK.
: Alcoholic hepatitis (AH) is a growing public health concern with its rising incidence and its contribution to nearly half of all cirrhosis-related deaths in the United States. In this systematic review, we aimed to comprehensively evaluate the current evidence and trials on the use of anti-interleukin-1 (anti-IL-1) drugs in patients with AH, assessing their efficacy and adverse events compared to routinely prescribed drugs like corticosteroids. : A comprehensive literature search was conducted across five databases to identify randomized controlled trials (RCTs) evaluating the role of anti-IL-1 agents like canakinumab and anakinra among patients diagnosed with AH.
View Article and Find Full Text PDF