Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Avian trichomoniasis is an important disease that causes bird mortality, both wild and captive, around the world. This study evaluated the in vitro cytotoxicity, antioxidant, and antiparasitic activity of citral (3.7-Dimetil-2.6-octadienal) and geraniol (trans-3.7-Dimetil-2.6-octadien-1-ol) against trophozoites.
Methods: In vitro assays were conducted at the Laboratory of Protozoology and Entomology (LAPEN) at the Federal University of Pelotas (UFPel), Brazil in 2019 using tests with 10 parasites and citral and geraniol at concentrations ranging from 10 to 100 μM and four controls: NC (culture medium and trophozoites), MTZ (trophozoites plus 100 μM of metronidazole), and TW (trophozoites plus vehicles used for solubilizing derivatives (0.01% Tween).
Results: The citral (60 μM) and geraniol (50 μM) concentrations reduced the trophozoites's viability by 100%. The molecular docking experiment demonstrated that citral and geraniol might inhibit a hydrogen enzyme for survival.
Conclusion: The major compounds of lemongrass have potential antitrichomonal activity against in vitro.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671819 | PMC |
| http://dx.doi.org/10.18502/ijpa.v19i4.17164 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Selective Oxidation of α,β-Unsaturated Alcohols With Lyophilisates of Bjerkandera adusta.
Chem Biodivers
August 2025
Institute of Food Chemistry and Food Biotechnology, Justus Liebig University Giessen, Giessen, Germany.
The biocatalytic aerobic production of (E)-2-allylic aldehydes from their corresponding alcohols using lyophilisates of the basidiomycetous fungus Bjerkandera adusta is reported. The addition of small amounts of organic solvents to the reaction media increased the reaction and substrate conversion rates, allowing for to produce (E)-aldehydes under sustainable conditions. Citral (mixture of (E)- and (Z)-3,7-dimethylocta-2,6-dienal) was found as a result of the oxidation of geraniol ((E)-3,7-dimethyl-2,6-octadien-1-ol) as well as of nerol ((Z)-3,7-dimethyl-2,6-octadien-1-ol).
View Article and Find Full Text PDFTherapeutic Potential of Citrus Species Against Metabolic Syndrome: Insights from Preclinical and Clinical Studies.
Curr Nutr Rep
August 2025
Faculty of Pharmaceutical Science, Assam down town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, Assam, PIN-781026, India.
Purpose Of The Review: Metabolic syndrome (MetSyn) is a multifactorial disorder affecting 12.5-31.4% of adults characterized by a cluster of conditions including obesity, type 2 diabetes, hypertension, cardiovascular diseases, and dyslipidemia.
View Article and Find Full Text PDFChemical Characterization, Cytotoxic Activity, and Antimicrobial Potential of Nanoemulsions Based on Essential Oils.
ACS Omega
August 2025
Department of Fishing and Fish Processing Technology, Faculty of Fisheries, University of Cukurova, Balcali, 01330 Adana, Turkey.
The essential oils (EOs) of (DC.) Stapf are globally recognized for their antimicrobial properties. However, their therapeutic potential is limited by their low solubility and potency.
View Article and Find Full Text PDFComputationally Designed Peroxygenases That Exhibit Diverse and Selective Terpene Oxyfunctionalization.
ACS Catal
August 2025
Institute of Chemistry, Martin Luther-University Halle-Wittenberg, Weinbergweg 22, Halle (Saale) 06120, Germany.
The selective oxyfunctionalization of terpenes remains a major challenge in chemical synthesis and is of significant industrial importance. This study presents a computational enzyme design approach based on an AlphaFold2 model of an unspecific peroxygenase (UPO). Using the FuncLib algorithm, only 50 variants were required, and they exhibit remarkable advancements.
View Article and Find Full Text PDFPhytochemical profile and antioxidant activity of Dracocephalum kotschyi boiss. affected by environmental conditions of cultivation regions.
BMC Plant Biol
July 2025
Department of Horticultural Science, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran.
Unlabelled: is a medicinal plant rich in antioxidant phytochemicals. Identifying the suitable cultivation region and evaluating the impact of environmental factors can help in choosing the best conditions for the commercial production of these herbs. The present study investigated the effect of different cultivation areas, Lasak (LSK), Saravarsu (SVS), and Sorkh Geriveh (SGV) on the glandular trichome density and phytochemicals of .
View Article and Find Full Text PDF